This National Science Foundation Project Grant of $510,011 was awarded to the University of Houston under the Biological Sciences federal grant program (CFDA 47.074) to support research on the oligomeric stoichiometry of superoxide dismutase 1 and its role in neuronal antioxidant defense. Specifically, the grantee will develop a quantitative single-molecule approach to quantify changes in superoxide dismutase 1 oligomerization in the cell nucleus, cytosol, and mitochondria under various...
This National Science Foundation (NSF) project grant, awarded under the Biological Sciences program (CFDA 47.074), will provide $1,225,175.00 to support a 3-year study at Wayne State University on the adaptation of the cytochrome c oxidase enzyme in response to hypoxic (low oxygen) conditions in systemic vascular cells. The key objectives are to: 1) characterize the dynamic regulation of cytochrome c oxidase subunit isoform composition in systemic pericytes and vascular cells under chronic...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $803,808 to New York University (NYU) to conduct quantitative structural and functional studies on the evolution of membrane transporter proteins. The key objectives are to understand how mutations impact the dynamics, conformational equilibria, and transport direction of these membrane proteins, which will provide insights into their biogenesis. The research will involve...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) project grant of $1,117,707 awarded to the University of South Carolina aims to better understand how organisms integrate the essential metal iron with core metabolic pathways. The project will use E. coli as a model organism to examine the molecular details of iron-sulfur (Fe-S) cluster formation and trafficking, including the role of monothiol glutaredoxins in this process and their interactions with proteins...
The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation...
This Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $950,000 to The Research Foundation For The State University Of New York from February 2023 through January 2026. The award supports research into regulating iron homeostasis by controlling the fate of intracellular ferritin. A multidisciplinary team will use structural biology, spectroscopy, microscopy, proteomics, and other analytical tools to delineate the mechanisms determining...
This $899,894 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (IA) program, CFDA 47.083, will support research to characterize the structure, membrane topology, substrate specificity, and biochemical properties of a unique mitochondrial HAD phosphatase enzyme in a divergent unicellular organism. The project aims to elucidate the dual functional roles of this enzyme, which may provide insights into the broader cellular functions of the related TIM50 protein...
This National Science Foundation Project Grant of $2,153,626 supports research at Michigan State University from July 2022 to June 2026 under the Biological Sciences program (CFDA 47.074). The funding will enable investigation of lipid-derived signaling involving chloroplasts in plants and the integration of biotic and abiotic stress responses. Graduate and undergraduate students will conduct experiments to isolate plant mutants and characterize their responses to stressors like cold, heat,...
This $900,052 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into the molecular mechanisms governing cytoskeleton-mediated motility and distribution of peroxisomes and mitochondria in plants. The grant supports three years of collaborative research between Michigan State University and its sub-awardee to advance understanding of how these organelles recruit cytoskeletal motor proteins for directional transport along...
This $600,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will support research at the University of Michigan and Trinity University to investigate the structural and electronic properties of high-valent cobalt, nickel, and copper-oxo complexes. The project aims to improve understanding of how metal-oxo versus metal-oxyl character impacts the stability and reactivity of these unstable, yet potentially useful,...