Project Grant 2401909
- This $638,454 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Dartmouth College to define the functions of an essential, conserved mitochondrial protein that links the organelle's matrix to the cytoplasm. Over three years, the researchers will investigate how specific mitochondrial components integrate mitochondrial function within plant cells, focusing on the roles of ATAD3 proteins that span the inner and outer...
- This $999,996 Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports fundamental research aimed at generating "designer mitochondria" for biotechnology, healthcare, and basic research applications. The key objectives are to identify the factors required for human mitochondrial DNA (mtDNA) replication and characterize the mechanisms underlying the species-specificity of this process. This work represents a critical step...
- This $900,052 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into the molecular mechanisms governing cytoskeleton-mediated motility and distribution of peroxisomes and mitochondria in plants. The grant supports three years of collaborative research between Michigan State University and its sub-awardee to advance understanding of how these organelles recruit cytoskeletal motor proteins for directional transport along...
- This $578,440 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research into defining the functions of an essential, conserved mitochondrial protein in plants. Over three years, the award supports collaborative investigations at San Diego State University into how specific mitochondrial components integrate mitochondrial function with the rest of the plant cell. Researchers will study ATPase Family AAA Domain-Containing Protein 3 (ATAD3)...
- This $1,000,000 four-year Project Grant from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund research at Northeastern University exploring the role of mitochondria in regulating cell fate decisions during early mammalian development. Specifically, the researchers will test the hypothesis that differential allocation of mitochondrial subtypes, which vary in biochemical properties and protein content including levels of the transcription factor TEAD4,...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $150,000.00 to the University of South Alabama to enhance the natural repair mechanisms of mitochondrial DNA (mtDNA). The project aims to improve the targeting of key DNA repair enzymes to mitochondria, which are essential cellular organelles, without disrupting their other cellular functions. By using a novel computational framework to optimize mitochondrial targeting...
- This federal Project Grant award of $946,895 from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) will fund research to advance the understanding of protein phosphorylation and its role in coordinating cell division. The project aims to identify new enzymes that carry out phosphorylation and the substrate proteins they modify to ensure proper cell division. Researchers will employ computational, biochemical, proteomic,...
- The National Science Foundation awarded a $138,000 Project Grant to support research from June 2021 to May 2023 titled "Uncovering the Molecular Mechanisms of Mitochondrial Proteostasis." The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing knowledge and enhancing understanding of major problems. Funds will support the grantee's research...
- This $820,000 Project Grant was awarded on July 15, 2023 by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The grant supports a collaborative research effort involving four research labs, two in the U.S. and two in Israel, to investigate RNA editing enzymes called ADARs (Adenosine Deaminases Acting on RNA). The goal is to advance the understanding of how ADAR enzymes can be used by different organisms to...
- This $493,073 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports collaborative research at the University of California, Santa Barbara (UCSB) on the evolutionary processes that enable a genus of ciliates known as Mesodinium to acquire and maintain phototrophy through organelle sequestration. The 3-year project will use comparative cellular, metabolic, and genetic analyses to understand the adaptations that allow some Mesodinium species to...
This $899,894 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (IA) program, CFDA 47.083, will support research to characterize the structure, membrane topology, substrate specificity, and biochemical properties of a unique mitochondrial HAD phosphatase enzyme in a divergent unicellular organism. The project aims to elucidate the dual functional roles of this enzyme, which may provide insights into the broader cellular functions of the related TIM50 protein in humans. The award will also provide hands-on research experiences for graduate and undergraduate minority students at local colleges and universities. This project aligns with the IA program's goals of advancing fundamental research, developing STEM workforce skills, and addressing complex national challenges across scientific disciplines. Sub-awards are planned under this grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $899.9k | 7/2/24 |