Project Grant 2344561

Award Date 5/1/24
Completion Date 4/30/28
Dollars Obligated $1.1M
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Columbia, SC 29208, USA
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This Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $950,000 to The Research Foundation For The State University Of New York from February 2023 through January 2026. The award supports research into regulating iron homeostasis by controlling the fate of intracellular ferritin. A multidisciplinary team will use structural biology, spectroscopy, microscopy, proteomics, and other analytical tools to delineate the mechanisms determining...
This National Science Foundation Project Grant of $1,255,705 will support research at the University of Missouri System from August 2022 to July 2025 to advance understanding of autonomous leaf-specific iron deficiency responses in plants. Funded through the NSF's Biological Sciences program (CFDA 47.074), the project aims to identify transcriptional complexes necessary to regulate iron homeostasis in leaves through time-series gene expression analysis, high-throughput DNA-protein and...
The National Science Foundation (NSF) awarded a $325,164 CAREER grant under its Engineering program (CFDA 47.041) to the University of South Carolina (USC) to conduct multiscale simulations of iron oxide nanoparticle-protein electron transfer. The goal is to elucidate the fundamental mechanisms of these nano-bio interactions to enable more efficient environmental applications using coupled iron oxide nanoparticles and metal-reducing bacteria. The 2-year project will integrate computational...
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The National Science Foundation Division of Molecular and Cellular Biosciences awarded Louisiana State University a $521,351 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) for the period of April 1, 2021 through March 31, 2024. The grant supports collaborative research titled "The Ferric Uptake Regulator (Fur) Regulates Intracellular Iron Homeostasis via Reversible Binding of a [2Fe-2S] Cluster in Escherichia coli." The research aims to increase...
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This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) project grant of $1,117,707 awarded to the University of South Carolina aims to better understand how organisms integrate the essential metal iron with core metabolic pathways. The project will use E. coli as a model organism to examine the molecular details of iron-sulfur (Fe-S) cluster formation and trafficking, including the role of monothiol glutaredoxins in this process and their interactions with proteins involved in cell envelope biogenesis. The research will combine microbial genetics, analytical chemistry, protein biochemistry, and quantitative mass spectrometry to provide insight into the crosstalk between Fe-S cluster biogenesis and cell envelope biogenesis. The project also includes a subgrant to Boston College to perform proteomic analyses. This research is expected to advance scientific understanding of cellular iron utilization and its connection to essential metabolic functions, while also providing research experiences for underrepresented minority STEM students.

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