Project Grant 2419893
- The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences program (CFDA 47.049), has awarded a $749,999 Project Grant to Princeton University and San Diego State University. The grant will fund the development of a novel method for tracking the synthesis, localization, and dynamics of RNA messages in living cells using metabolically incorporated fluorescent nucleosides. This innovative approach will enable researchers to study the organization of cellular structures...
- This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences provides $300,000 to the University of California, San Diego for research titled "EAGER: DEVELOPING A HIGHLY SELECTIVE, ORTHOGONAL, ENZYMATIC RNA LABELING TECHNOLOGY VIA DIRECTED EVOLUTION OF AN RNA TRANSGLYCOSYLASE." The period of performance is from August 15, 2021 to July 31, 2023. The funding supports research under the NSF's Biological Sciences program (CFDA 47.074). The goal...
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $522,131.00 to New York University (NYU) from August 1, 2023 to July 31, 2026. The funded research aims to understand the relationship between RNA sequence features and splicing outcomes, as well as the role that nuclear speckles play in RNA splicing decisions. The project will leverage high-throughput assays and interpretable machine learning to identify sequence-encoded...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences (CFDA 47.049) federal grant program, awarded a $500,000 Project Grant to the University of California, Irvine (UCI) to investigate splicing, a fundamental cellular process that produces multiple distinct proteins from the same gene. This research aims to uncover the rules governing RNA splicing dynamics, which are essential for healthy development but linked to diseases like cancer and neurodegeneration. The...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $800,000.00 aims to dramatically expand the understanding of RNA modification enzymes (RMEs) - a class of proteins that chemically alter RNA molecules and influence their function, stability, and therapeutic potential. The project will systematically identify and assay over 750 RMEs from nearly 100 microbial organisms to establish foundational knowledge and resources to...
- The National Science Foundation (NSF) has awarded a $741,544 Project Grant under the Biological Sciences program (CFDA 47.074) to investigate how dormant yeast cells reorganize their cellular machinery, particularly the ribosomes that produce proteins. The principal investigators, Dr. Ahmad Jomaa at the University of Virginia and Dr. Simone Mattei at the EMBL Imaging Center in Germany, will use advanced imaging and molecular biology techniques to understand how ribosomes become inactive by...
- This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
- This $700,000 Project Grant was awarded by the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program to the University of California, San Diego (UCSD) on August 1, 2025. The grant funds a 3-year research project to investigate how bacteria use RNA "switches" called riboswitches to regulate the import and export of metal ions, which are important for cellular function but can be toxic in excess. Specifically, the project aims to map the co-transcriptional...
- This National Science Foundation (NSF) Biological Sciences program grant to Yale University, totaling $940,000 over 3 years beginning March 1, 2024, aims to systematically identify features of human and viral messenger RNAs (mRNAs) that regulate protein production. The project will employ a massively parallel reporter assay to quantify the impact of RNA modifications, structured RNA elements, and cell-specific factors on mRNA translation. Insights gained will provide a comprehensive...
The National Science Foundation (NSF) awarded a $299,529 Project Grant to the University of California, San Diego (UCSD) under the Biological Sciences program (CFDA 47.074) to develop novel "LOC-SEQ" technologies for genome-wide screening of factors affecting mRNA localization. This research aims to bridge the gap between identifying spatially localized RNAs and understanding the mechanisms directing their localization, initially focusing on mitochondrial localization in yeast and later adapting the technology to mammalian cells. The project will establish the feasibility of the LOC-SEQ approach and provide opportunities for interdisciplinary scientific training. This research has the potential to significantly advance the understanding of RNA localization mechanisms, which play crucial roles in various cellular functions. The award period is from July 15, 2024, to June 30, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $299.5k | 7/2/24 |