The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $837,500 to Yale University over the period of August 8, 2024 to June 30, 2029 to support research on post-transcriptional control of gene expression by the mTORC1 signaling pathway. The research program aims to answer key questions about the molecular mechanisms that regulate cap-dependent and cap-independent translation of...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $949,953 Project Grant to the Research Foundation Of The City University Of New York, doing business as Rfcuny - Hunter College, from August 1, 2023 to July 31, 2026. The grant, funded under the Biological Sciences program (CFDA 47.074), will support research to identify molecular interactions and build a detailed model of translational regulation, specifically examining the role of eIF3 and 4E-BP in...
This $3,000,000 project grant awarded by the National Science Foundation (NSF) under CFDA 47.041 - Engineering will address a decades-long challenge in the field of self-amplifying ribonucleic acid (saRNA). The project led by Trustees of Boston University aims to develop modified saRNA with increased cellular half-life, enabling longer-lasting protein expression compared to traditional mRNA technologies. The research team will: Synthesize a library of modified nucleoside triphosphates...
The National Science Foundation awarded a $276,000 Project Grant to an individual located in Seattle, Washington under the Biological Sciences federal grant program (CFDA 47.074). The two-year award will fund research defining the link between genetic variation in human populations and messenger RNA stability. The fellow will use high-throughput experimental and computational approaches to identify amino acid motifs that alter mRNA stability. This includes a novel massively parallel knock-in...
This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
The National Science Foundation (NSF) Division of Integrative Organismal Systems awarded a $299,983 Project Grant to North Carolina State University (NCSU) under the agency's Biological Sciences program (CFDA 47.074). The objective of this 2-year grant is to develop a new biotechnology called RIBOPI that will enable efficient, scalable, and cost-effective quantification of gene-specific translation regulation. RIBOPI aims to make translation regulation analysis as accessible as RNA sequencing...
The National Science Foundation (NSF) awarded a $299,529 Project Grant to the University of California, San Diego (UCSD) under the Biological Sciences program (CFDA 47.074) to develop novel "LOC-SEQ" technologies for genome-wide screening of factors affecting mRNA localization. This research aims to bridge the gap between identifying spatially localized RNAs and understanding the mechanisms directing their localization, initially focusing on mitochondrial localization in yeast and...
This $324,118 National Science Foundation project grant supports research to decipher RNA-based regulatory logic through interpretable machine learning models. Funded under the Mathematical and Physical Sciences program (CFDA 47.049), the three-year award to New York University will develop and apply interpretable neural networks to massive parallel reporter assay datasets. Specifically, the models aim to elucidate the splicing code that determines exon skipping and the 5'UTR code regulating...