This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) totaling $329,172 funds a collaborative research project to investigate how the SMC5/6 protein complex manages branched DNA structures during DNA repair processes. The research teams at North Carolina State University will use complementary biochemical and high-speed atomic force microscopy (HS-AFM) methodologies to examine how SMC5/6 recognizes and processes key DNA repair...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $445,000.00 in funding to the Dana-Farber Cancer Institute, Inc. (DFCI) to support research on the molecular mechanisms of DNA double-strand break repair by homologous recombination. The primary goal of this 5-year project is to elucidate the fundamental mechanisms of homologous recombination, a high-fidelity DNA repair pathway whose...
This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...
This $246,424 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at the University of California, Santa Barbara (UCSB) to study the initiation and early steps of recombination at DNA double strand breaks. The award aims to leverage novel methods to understand how cells choose different DNA repair mechanisms, with a focus on recombination, which maintains genetic information. The research will have broad...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $910,000 over 4 years to Weill Medical College of Cornell University to conduct research on the regulation of DNA repair mechanisms and transcription at telomeres. The research aims to improve understanding of how genetic information is protected at chromosome ends, which is critical for cell and organism health. The...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $350,000 to the University of Iowa to support research on the mechanisms involved in the propagation of chromosome fragments in the germline. The 3-year project aims to investigate how DNA breaks that occur during the formation of egg and sperm cells are stabilized and passed on to the next generation. The research will be conducted using the model organism C. elegans and will...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,637,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Johns Hopkins University to support a 5-year research project titled "Probing the Mechanisms that Control DNA Repair Pathway Choice." The project aims to investigate how chromatin plasticity and RNA modifications regulate DNA repair mechanisms in response to various DNA lesions, with the goal of advancing understanding of...
The National Science Foundation (NSF) awarded a $650,000 Project Grant under the Biological Sciences (CFDA 47.074) program to the Research Foundation of the City University of New York (RFCUNY) - Brooklyn College. The grant, awarded on April 1, 2025, will support a 3-year research project exploring the precise mechanisms of DNA replication during plant cell division using the single-celled eukaryote Chlamydomonas reinhardtii as a model organism. This research aims to deepen undergraduate student...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,350,554 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research in New York, NY. This 5-year grant, effective August 10, 2024 through July 31, 2029, will support research to illuminate the molecular mechanisms of eukaryotic chromosome replication and investigate how DNA replication stress impacts genome stability and disease. The project aims to...
This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $300,000 to the University of Kansas Center for Research Inc. from February 1, 2023 to January 31, 2025. The award will support research investigating delivery and trafficking of DNA introduced to cells from environmental sources using the genetically tractable organism Caenorhabditis elegans. The project aims to gain new...