This $262,588 National Science Foundation Project Grant under the Geosciences program (CFDA 47.050) will support research into prebiotic chemistry processes relevant to the origin of life on Earth. The Foundation For Applied Molecular Evolution, Inc. will use the funding to advance scientific understanding of geological environments on Earth 4.35 billion years ago that could have facilitated the emergence of the first genetic molecules. Key deliverables include completing structural analysis...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant, awarded to the University of Texas Rio Grande Valley (UTRGV), seeks to understand how simple chemical building blocks can self-assemble into membrane-encapsulated protocells, and whether these protocells can display a primitive form of evolution through natural selection. The $502,983 award will support research with three main goals: (1) using catalytic minerals to promote the synthesis and polymerization of...
This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...
The National Science Foundation Division of Environmental Biology awarded a $1,126,538 project grant to the University of Wisconsin-Madison under the Biological Sciences federal grant program (CFDA 47.074) to support research exploring the origin of life through ecological dynamics and adaptive evolution. Over a three-year period from August 2022 to July 2025, the university will conduct both theoretical and laboratory research to test the hypothesis that the earliest adaptive evolution occurred...
This $303,254 Project Grant from the National Science Foundation's Division of Environmental Biology, under the Biological Sciences program (CFDA 47.074), will fund research exploring the idea that the earliest adaptive evolution occurred through self-amplifying cycles of chemical reactions, rather than nucleic acids. Over a three-year period from August 2022 to July 2025, Michigan State University will conduct theoretical and laboratory studies to analyze how mixtures of chemicals could...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $100,000 to the Georgia Tech Research Corporation to advance protein engineering through a novel interdisciplinary approach combining artificial intelligence (AI) methods and automated laboratory experimentation. The research aims to greatly accelerate the discovery of new proteins with enhanced properties, offering significant potential impact across scientific domains...
This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) will support research to investigate the roles of amino acid isomerization, a chemical modification that affects the structure and function of cell-cell signaling peptides. The $681,070 award to the Board of Regents of the University of Nebraska, which operates as the University of Nebraska, aims to provide critical insights into how living systems alter their cellular communication...
This Project Grant award of $104,917 from the National Science Foundation's (CFDA 47.074) Biological Sciences program will support a team of undergraduate students at the University of Virginia in developing a low-cost treatment for exocrine pancreatic insufficiency. The students will design and build a probiotic that secretes synthetic pancreatic enzymes, with the goal of providing this treatment solution for the International Genetically Engineered Machines (iGEM) competition in synthetic...
This $461,575 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Earlham College to investigate how a bacterial enzyme, ProXP-X, recognizes and distinguishes between L- and D-amino acids, and how it protects bacterial cells from D-amino acid toxicity. The key goals are to characterize how ProXP-X binds and identifies its targets, and determine if its activity prevents D-amino acid toxicity in living bacteria. The...