This $262,588 National Science Foundation Project Grant under the Geosciences program (CFDA 47.050) will support research into prebiotic chemistry processes relevant to the origin of life on Earth. The Foundation For Applied Molecular Evolution, Inc. will use the funding to advance scientific understanding of geological environments on Earth 4.35 billion years ago that could have facilitated the emergence of the first genetic molecules. Key deliverables include completing structural analysis...
This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
This $299,779 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) funds research at Louisiana State University from August 2022 to July 2024 to design an RNA-based dual regulator for repetitive gene expression regulation. The research integrates biological experiments and computational studies to train scientists and engineers in interdisciplinary research. It also aims to cultivate a multidisciplinary perspective for problem-solving. Specifically, the...
This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
This $502,983 National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant awarded to the University of Texas Rio Grande Valley (UTRGV) on March 1, 2025 supports research to understand how membrane-encapsulated vesicles (protocells) may have formed and reproduced without genetic information during the emergence of life on Earth. The key goals are to: (1) use catalytic minerals to promote the synthesis and polymerization of organosulfur species into amphiphilic...
The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant titled "TRANSITIONS: EVOLVING OUR UNDERSTANDING OF DYNAMIC RNA FOLDING AND FUNCTION" to Northwestern University under the Biological Sciences grant program (CFDA 47.074). The objective of this 3-year award is to uncover fundamental principles linking RNA sequence to dynamic RNA folding processes and function in biological systems. The research aims to enhance the...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
This $1,042,995 National Science Foundation project grant, awarded on March 15, 2023 under the Biological Sciences (47.074) program, funds research at Oregon State University and Mount Holyoke College to discover novel functional RNA classes through computational integration of massively parallel RNA-binding protein binding and structure data. The grantees will develop new experimental and computational methods to systematically identify unknown non-coding RNA classes by combining known and...
This $171,515 federal Project Grant award, funded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports research to investigate RNA self-repair mechanisms induced by sunlight. The primary awardee, President and Fellows of Harvard College, will conduct experiments to elucidate the mechanism of RNA self-repair and explore its potential implications for the origins of life and modern RNA function in cells and viruses. The research aims...