This National Science Foundation (NSF) Project Grant award, funded under the Integrative Activities program (CFDA 47.083), supports research on the structural mechanisms of bacterial extracellular DNA-recognition. The $216,149 award to the Board of Regents of the University of Nebraska, from July 1, 2023 to June 30, 2026, aims to identify and characterize novel DNA receptor subunits incorporated into bacterial surface appendages. The project will purify soluble protein constructs, measure...
The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation...
The National Science Foundation awarded a $1,109,203 Project Grant to The Research Foundation For The State University Of New York to elucidate the role of protein arginine methylation in regulating RNA-binding protein function from May 2021 through April 2025. This award supports research under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing scientific knowledge and...
This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
This National Science Foundation project grant award of $270,728 provides funding from August 1, 2022 through July 31, 2025 to support research exploring self-organization of functional nucleic acid supramolecular assemblies with stimuli responsive properties. Funded under the NSF Integrative Activities program (CFDA 47.083), the award supports the University of Nebraska at Omaha and its parent institution, the Board of Regents of the University of Nebraska, in developing a toolkit for...
This $461,575 Project Grant awarded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at Earlham College to investigate how the bacterial enzyme ProXP-X recognizes and binds to both L- and D-amino acids. The project aims to determine the specific mechanisms by which ProXP-X distinguishes between L- and D-amino acids, as well as how this enzyme protects bacterial cells from the toxicity of D-amino acids. The findings will advance the...
The Board of Regents of the University of Nebraska received a $649,999 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences on August 15, 2021 to support research titled "Nanoscale Structure and Dynamics of Nucleosome Arrays Assembled on DNA Templates with Physiologically Relevant Sequences." The award is part of the NSF's Biological Sciences program (CFDA #47.074), which aims to promote progress in the biological sciences and...
The National Science Foundation, through its Division of Chemistry and the Mathematical and Physical Sciences program (CFDA 47.049), awarded a $577,690 Project Grant to the University of North Carolina at Chapel Hill from July 1, 2023 through June 30, 2027. The grant supports research to characterize the biosynthetic pathways of dehydroamino acids in nonribosomal peptides, which are biologically and industrially important natural products. The research aims to understand the molecular details of...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant awarded to Adelphi University for $311,035 provides funding to identify prebiotic peptides or small proteins that may have played a role in the origin of biological energy generation at the start of cellular life. The 3-year project aims to use artificial intelligence and experimental validation to discover prebiotic oxidoreductases composed only of amino acids available under prebiotic conditions, which could...
This Project Grant award of $360,000 from the National Science Foundation's Biological Sciences (CFDA 47.074) program aims to investigate the role of neuron-neuron communication, particularly neurotransmitter-based and neuropeptidergic chemical neurotransmission, in the post-mitotic maturation of neurons during postnatal development. The research will utilize the model organism Caenorhabditis elegans and leverage advanced genetics, behavioral assays, microscopy, and genomics tools to examine the...