This $3,949,992 Project Grant award from the National Science Foundation (NSF) Office of International Science and Engineering (CFDA 47.079) supports the development of standards, metrics, and best practices to enable the wide-scale adoption of reliable and scalable biofoundries for biomanufacturing and the global bioeconomy. The primary awardee, the University of Illinois, is leading an international consortium of seven successful biofoundries from the U.S., Finland, Japan, South Korea, and the...
This Project Grant award for $1,000,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a polyketide-based platform to produce a range of non-canonical amino acids (NCAAs) and demonstrate their incorporation into proteins expressed by the bacterium Bacillus subtilis. The key objectives of the 3-year project are to: 1) engineer a polyketide synthase (PKS) system to produce threonine and evolve it for increased productivity; 2) utilize...
This federal Project Grant award, with a total funding of $7,545,897.00, was provided by the National Science Foundation (NSF) under the STEM Education (CFDA 47.076) program. The award will support the establishment of the InnovateBio National Biotechnology Education Center, which aims to expand training and education opportunities in biotechnology and biomanufacturing to maintain U.S. leadership in the bioeconomy. The center will focus on educating the skilled technical workforce needed by...
This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
This $2,963,428 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) aims to develop critical infrastructure and tools for interpreting genomic data. The project will create high-quality genome assembly workflows, comprehensive documentation, and interactive training materials to make these advanced genomic analysis capabilities accessible to a wide audience of biology researchers. This will enable downstream discoveries in areas such as...
This $2,996,108 Cooperative Agreement award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program is supporting the development of more efficient cell-free biomanufacturing processes. The project aims to create a robust, reusable platform capable of sustaining multi-enzyme cascades for the efficient synthesis of high-value, enantio-enriched products such as chiral amines and alcohols. This will be achieved by introducing membrane-less...
This Project Grant award of $408,007 from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop a technology called "glycosequencing" that uses next-generation sequencing (NGS) to sequence and quantify glycan structures. The project will first identify an optimal set of lectins, biochemically characterize them, and prepare lectin barcoding for NGS. It will also build a training dataset using recombinant proteins produced in glycoengineered Chinese...
This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) Project Grant of $579,734 awarded to Rutgers, The State University, aims to accelerate the design and development of synthetic enzymes through a combination of artificial intelligence, polymer science, and robotics. The project will implement an iterative design-build-test-learn process to reveal the underlying structure-function relationships that can produce enzyme mimetic...
The National Science Foundation (NSF) awarded a $600,000 Project Grant under the Computer and Information Science and Engineering program (CFDA 47.070) to Trustees of Dartmouth College to support the development of an "Emerging Technology Tool for Rapid Drug-Cocktail Formulation." The project aims to create a technology platform that leverages the mathematical equivalence between biological and electronic circuits to enable rapid, high-throughput discovery of optimal drug cocktails for...
This $300,000 Project Grant award from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) is funding research at the University of New Mexico (UNM) to develop novel computational tools for designing and validating DNA nanodevices. The goal is to integrate high-level kinetic models with low-level molecular dynamics simulations to streamline the design process for DNA-based molecular systems, including "heterochiral" DNA structures that are more...
This $600,000 Project Grant award, funded by the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083), supports the establishment of the Center for Robust, Equitable and Accessible Technology and Education (CREATE) for Next Generation Biofoundries. The primary objectives are to develop methods for designing and building large genetic system libraries and metabolic pathways at significantly lower cost compared to conventional approaches. Key activities include:
Constructing large genetic system libraries using massively parallel oligonucleotide assembly and combinatorial pathway engineering techniques.
Developing educational and workforce development tools to train biotechnologists on high-throughput design, building, and testing methodologies.
Engaging the community to prioritize sensor development and identify future users of CREATE's resources.
Sub-awards to Worcester Polytechnic Institute and Pennsylvania State University will contribute to building capabilities for large-scale genetic system assembly and web-based user interfaces to improve accessibility. The award reflects NSF's mission to advance scientific discovery and technological innovation through interdisciplinary collaboration.