This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award provides $274,932 to Femtofluidics Incorporated to develop hardware that can rapidly and inexpensively synthesize DNA-encoded libraries (DELs) for drug discovery. The project aims to create an electronic device that can manipulate nanoliter to picoliter volume droplets to perform combinatorial chemistry, overcoming limitations of traditional liquid-handling robots. This technology...
The National Science Foundation (NSF) awarded a $327,311 Project Grant under the Computer and Information Science and Engineering (CISE) Federal Grant Program (CFDA 47.070) to Trustees of Dartmouth College to conduct collaborative research on connections between optimization methods and property testing for processing large data sets and developing accurate predictive models. The three-year project, which began on April 1, 2024, aims to discover mathematical relationships between sublinear...
The National Science Foundation (NSF) Division of Electrical, Communications and Cyber Systems awarded a $399,541 Project Grant to the Trustees of Dartmouth College to develop a high-throughput, label-free, and portable sensor that can quantitatively detect multiple illicit drugs including opioids, cocaine, psychostimulants, and methadone in liquid samples such as biofluids. The project aims to create a silver or gold nanoparticle-decorated zinc oxide nanorod coated silica nanofiber matrix...
This Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) is funding the development of an engineered cyber-physical system to accurately predict patient responses to anti-cancer therapies. The $275,956 award to the University of Massachusetts Lowell will leverage expertise in biofabrication, tissue engineering, microfluidics, bioanalysis, and artificial intelligence to construct biomimetic, vascularized...
This two-year Project Grant from the National Science Foundation Division of Computing and Communication Foundations provides $250,000 to Dana-Farber Cancer Institute, Inc. for research titled "COLLABORATIVE RESEARCH: FET: MEDIUM: BIOLOGICAL PRODUCTION AND ENZYMATIC PROCESSING FOR DEFECT-FREE, SCALABLE NUIC-ACID CIRCUITS." The funding supports investigator-initiated research and education efforts under the official federal grant program "Computer and Information Science and...
This $1,200,000 Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of innovative sensing technologies that integrate DNA nanotechnology and CMOS electronics for next-generation diagnostics.
The key objectives of this 4-year project are to: 1) develop molecular engineering techniques for in-situ signal amplification of aptamer biosensors using DNA origami nanotechnology; 2)...
This Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) provides $300,000 to the Massachusetts Institute of Technology (MIT) to develop a novel biological computing platform based on programmable DNA molecules. The project aims to explore the limits of data storage and computing capabilities of individual DNA templates and their spatial patterns across large-scale surfaces. Key goals include increasing...
This $600,000 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (IA) program, titled "BIOFOUNDRY: CENTER FOR ROBUST, EQUITABLE AND ACCESSIBLE TECHNOLOGY AND EDUCATION (CREATE) FOR NEXT GENERATION BIOFOUNDRIES", aims to democratize and decentralize biofoundry capabilities. The award will advance three key technological approaches: 1) building large genetic system libraries from low-cost oligonucleotide pools, 2) designing synthetic metabolic...
This National Science Foundation Project Grant of $606,649 will support the development of an engineered cyber-physical system combining advanced biological models and artificial intelligence methods to enable precision medicine for cancer treatment. Awarded under the Computer and Information Science and Engineering program, the funding will be used by Brigham and Women's Hospital and its parent organization Partners Healthcare System from October 2022 to September 2025. Specifically, the...
The National Science Foundation awarded Dartmouth College $520,267 under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) from July 1, 2023 to June 30, 2026. Dartmouth will conduct research on hydrazone-based feedback loops to study how molecular switches can communicate and be used to control ensembles of molecules. This work aims to further fundamental understanding of engineering reaction cascades and self-assembling systems that can autonomously regulate...