The National Science Foundation (NSF) awarded a $408,007 Project Grant under the Engineering program (CFDA 47.041) to the University of California, San Diego (UCSD) to develop a novel glycosequencing technology using next-generation sequencing. The goal is to rapidly and inexpensively sequence and quantify glycan structures, which are critical for the development and characterization of biotherapeutic drugs. The project aims to identify optimal lectins, barcode them, and use AI to map lectin binding patterns to glycan structures. UCSD will first validate the technology on recombinant protein drugs and then use it to profile glycans and mRNA of production host cells cultured under different media conditions. This research will accelerate the characterization and engineering of glycoproteins for biomanufacturing applications. The award period runs from July 2024 to June 2027.
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