Project Grant 2342509

Award Date 6/1/24
Completion Date 5/31/28
Dollars Obligated $356K
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Syracuse, NY 13210, USA
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This $214,612 federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund a collaborative research project to investigate how the antimicrobial functions of immune cells, specifically neutrophils, scale with body mass in terrestrial mammals. The project, led by The Research Foundation for the State University of New York (Upstate Medical Center), aims to understand how neutrophil antibacterial responses, gene expression, and energetics...
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This $356,334 project grant, awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074), will investigate how the antibacterial functions of neutrophil immune cells scale with body mass across diverse terrestrial mammal species. The research team from The Research Foundation For The State University Of New York will assess neutrophil activities like direct bacterial killing, phagocytosis, and generation of reactive oxygen species in mammals ranging from mice to elephants. The project aims to enhance understanding of how body size constraints the evolution of innate immune defenses in vertebrates. Key deliverables include transcriptomic data, a database of neutrophil defense images, and the development of museum exhibits and educational programming to engage middle school students in the Syracuse city school district on comparative biology and STEM topics. The project period runs from June 1, 2024 to May 31, 2028.

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