Project Grant 2316470

Award Date 8/15/23
Completion Date 7/31/27
Dollars Obligated $614K
Funding Federal Agency
Division of Emerging Frontiers
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Rochester, NY 14627, USA
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The project aims to use a multidisciplinary approach integrating immunology, evolutionary biology, and mathematical modeling to study how T cell immunity changes as amphibians, like frogs, progress from younger to older life stages. Specific objectives include predicting when evolutionary history, pathogens, and environment favor T cell diversity; quantifying T cell receptor diversity across frog species; and experimentally manipulating early-life diet and environment to assess developmental plasticity in frog T cell diversity and infection outcomes. The findings are expected to yield insights into the factors driving the evolution of immune system maturation, plasticity, and diversity, while also training early-career scientists in interdisciplinary immunology research.

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