The National Science Foundation (NSF) Division of Emerging Frontiers awarded a $613,690 Project Grant to the University of Rochester to investigate the evolution of immune investment strategies across amphibian ontogeny. The project, titled "Collaborative Research: INTBIO: The Evolution of Immune Investment Strategies Across Amphibian Ontogeny," falls under NSF's Biological Sciences (CFDA 47.074) program, which supports basic research to strengthen the nation's scientific enterprise. The project aims to use a multidisciplinary approach integrating immunology, evolutionary biology, and mathematical modeling to study how T cell immunity changes as amphibians, like frogs, progress from younger to older life stages. Specific objectives include predicting when evolutionary history, pathogens, and environment favor T cell diversity; quantifying T cell receptor diversity across frog species; and experimentally manipulating early-life diet and environment to assess developmental plasticity in frog T cell diversity and infection outcomes. The findings are expected to yield insights into the factors driving the evolution of immune system maturation, plasticity, and diversity, while also training early-career scientists in interdisciplinary immunology research.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $613.7k | 8/16/23 |