This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $199,982 to Wesleyan University to investigate the principles governing the interactions at the interface between different groups of cells. The research aims to understand how cells from different tissues interact and organize themselves when they come into contact, which is crucial for processes like tissue development, wound healing, and cancer metastasis. The project will use...
The National Science Foundation (NSF) Engineering program awarded a $377,755 Project Grant to the University of New Haven, Incorporated to support fundamental research on the mechanoregulation of collective cell migration in biomimetic microenvironments. This 3-year grant, effective from September 1, 2024 to August 31, 2027, will enable the University of New Haven to investigate how mechanical forces and biochemical factors interact to regulate collective cell migration, a crucial process in...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $123,956 Project Grant to New Mexico State University (NMSU) through the Biological Sciences program (CFDA 47.074) to support a 3-year research project. The project will probe the role of the small GTPase Rap1 protein in the mechanisms that drive morphogenesis - the changes in cell and tissue shape and arrangement during development. The goals are for the Principal Investigator to learn and apply...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $440,454 to The Washington University to study epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The project will investigate how epithelial cells sense and respond to extracellular matrix properties, force transmission, and nuclear mechanosensing in the context of processes like wound...
The National Science Foundation awarded a 5-year, $314,001 Project Grant under the Engineering program (CFDA 47.041) to the Board of Regents of the Nevada System of Higher Education, operating through the University of Nevada, Reno. The grant will fund research to engineer and design new multifunctional protein inhibitors capable of selectively targeting multiple extracellular matrix (ECM) proteins. The objective is to develop these multifunctional protein scaffolds to better understand the...
The National Institute of General Medical Sciences (NIGMS) awarded a $389,211 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Massachusetts (UMass) Amherst. The grant, which runs from July 2024 to June 2029, will fund research to investigate the biophysical and molecular mechanisms underlying a novel process of "meso-scale gap closure" in tissues undergoing epithelial-mesenchymal transition. The research aims to...
This National Science Foundation (NSF) Biological Sciences program project grant, awarded to Oregon Health & Science University (OHSU), aims to uncover the underlying biophysical mechanisms of directed cell migration. The $1,049,497 grant, with a period of performance from January 2024 to December 2027, will examine how actin cytoskeletal networks and adhesion receptors interact as interdependent subsystems to facilitate matrix-guided cell migration, which is crucial for tissue formation and...
This National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences project grant for $300,000 aims to engineer shape-morphing materials as cell sheet culturing substrates to develop human tissues with controllable shape, cellular composition, and morphology. The 3-year project, beginning on September 1, 2023, will use thermoresponsive hydrogels to enable cell sheet expulsion and explore how material characteristics impact stem cell fate. Additionally, the project seeks...
This $349,999 Project Grant, awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), aims to create a new biomaterial platform that can precisely control the composition and stiffness of the extracellular matrix (ECM) to investigate how these factors influence airway basal stem cell (BC) self-renewal and differentiation. The interdisciplinary research combines expertise in materials science, stem cell biology, and regenerative medicine to develop an advanced...