The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
This National Science Foundation (NSF) Biological Sciences program project grant, awarded to Oregon Health & Science University (OHSU), aims to uncover the underlying biophysical mechanisms of directed cell migration. The $1,049,497 grant, with a period of performance from January 2024 to December 2027, will examine how actin cytoskeletal networks and adhesion receptors interact as interdependent subsystems to facilitate matrix-guided cell migration, which is crucial for tissue formation and...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded Colorado State University Sponsored Programs Division a $949,949 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program. The award period is from June 15, 2023 through May 31, 2027. Through this funding, Colorado State University will investigate the cellular machinery that carries out endocytosis, a process by which cells take up nutrients and communicate. Researchers will study...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $139,341 project grant to the Regents of the University of California, San Francisco (UCSF) under the NSF Biological Sciences program (CFDA 47.074). The 3-year grant, effective August 1, 2023, supports collaborative research to investigate the biomechanical mechanisms underlying wound resilience in the single-celled organism Stentor coeruleus. The research will leverage cell biology, microfluidics, and...
The National Science Foundation (NSF) awarded a $100,000 CAREER grant under the Biological Sciences program (CFDA 47.074) to the Regents of the University of California at Riverside (UC Riverside) to develop a multiscale mathematical model for understanding the mechanisms underlying cell morphogenesis and tissue development in plant leaves. The 5-year project aims to improve understanding of the general principles that govern cell shape formation and tissue growth, using the interdigitated...
This National Science Foundation Project Grant award of $250,000 supports research at Louisiana State University from May 1, 2022 to April 30, 2025 under the Integrative Activities program. The research aims to define signaling pathways that control cytoskeletal networks during epithelial tube formation using the developing salivary glands of Drosophila melanogaster. Specifically, the project will identify and characterize unidentified salivary gland G protein-coupled receptors that reorganize...
This Project Grant award of $630,000 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) was provided to the University of New Mexico (UNM) to develop an advanced optical microscopy system that combines MinFlux and modal imaging techniques. The goal is to dramatically improve the ability to study how proteins cluster and interact on the membranes of living cells, which has the potential to significantly advance the understanding of cell signaling and its...
The University of New Mexico was awarded a $414,071 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The grant will support collaborative research toward developing lifelike synthetic cells through engineered control of DNA replication from August 15, 2021 to July 31, 2024. The Biological Sciences program aims to promote advancement in the biological sciences and strengthen the...
This Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049), focuses on developing a new generation of computational models to study eukaryotic cell motility, especially in complex geometries. The $380,000 award, granted to Northeastern University, supports a joint experiment-theory project to gain a quantitatively predictive understanding of cell motility processes, including how cells utilize "blebbing" and...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded Emory University a $724,356 Project Grant under the Biological Sciences program (CFDA 47.074) to investigate the role of the protein ARL13B in controlling ciliary cyclic AMP (cAMP) signaling. The research aims to unravel the ciliary cAMP "signature", optogenetically stimulate cAMP signaling within normal and ARL13B-excluded cilia, investigate the role of ciliary cAMP signaling in remodeling...