The National Science Foundation (NSF) Engineering program awarded a $377,755 Project Grant to the University of New Haven, Incorporated to support fundamental research on the mechanoregulation of collective cell migration in biomimetic microenvironments. This 3-year grant, effective from September 1, 2024 to August 31, 2027, will enable the University of New Haven to investigate how mechanical forces and biochemical factors interact to regulate collective cell migration, a crucial process in biological phenomena such as embryonic development, wound healing, and cancer metastasis. The research aims to develop novel multiplex nanobiosensors to detect non-coding RNAs at the single-cell level, elucidate the mechanosensitive role of non-coding RNAs, and investigate their regulation of collective cell migration in 3D biomimetic microenvironments. Broader impacts include advancing fundamental science, developing course curricula and research opportunities, and engaging high school and undergraduate students, with a focus on women and underrepresented minority groups.
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