This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This $314,769 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) supports research that aims to advance the fundamental understanding of how cells and tissues communicate information about their mechanical environment. The award, effective from February 1, 2025 to January 31, 2030, will fund the development of new material platforms based on magnetic materials that can dynamically change local stiffness via magnetic fields. Experiments will explore how...
This is a $675,234 Project Grant awarded on August 1, 2024 by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049). The grant recipient is the Texas A&M Engineering Experiment Station (Tees), a state government agency and institute of higher learning. The grant will fund research to develop a new class of "shape-morphing" polymer materials that can transform their shape in response to temperature changes, without requiring...
This National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) Project Grant award of $330,000 supports theoretical and computational research by the University of California, Merced to describe and understand the behavior of biologically-inspired active solids. The research aims to create models that combine mechanical and chemical factors to investigate the unique shape changes and self-organization phenomena possible in active solids, such as those found in cell...
The National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences awarded a $399,755 Project Grant to the University of California, Santa Barbara (UCSB) under the Mathematical and Physical Sciences program (CFDA 47.049). The grant funds the development of new mathematical modeling paradigms and simulation software tools for investigating cell mechanics across multiple scales. This includes contributions from cell membranes and the cytoskeleton, and the roles of geometry,...
The National Science Foundation awarded a $192,089 Project Grant to the University of Chicago under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) for research titled "Co-Dynamics of Contraction and Adhesion in Animal Morphogenesis." The three-year award beginning March 1, 2022 will support research using advanced microscopy, genetic and biophysical manipulations, and mathematical modeling to gain new insights into the mechanisms governing rapid tissue...
This $300,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) aims to enhance the design of fluorinated protein fibers and hydrogels for medical use. The key objectives are to: 1) generate coiled-coil fluorinated fibers for controlled drug encapsulation, 2) develop fluorinated coiled-coil hydrogels that can change with temperature, and 3) assess the potential of these fluorinated materials as imaging agents for 19F...
This National Science Foundation (NSF) CAREER award under the Mathematical and Physical Sciences program (CFDA 47.049) provides $152,007 to the University of New Hampshire (UNH) to develop a simplified "bottom-up" approach for engineering liquid-liquid phase separation and microstructural heterogeneity in polysaccharide-based hydrogels. The project aims to leverage this novel technique to create customizable hydrogel microstructures and investigate their impact on cellular behavior,...
This National Science Foundation (NSF) Division of Materials Research award, under the Mathematical and Physical Sciences program (CFDA 47.049), provides $392,000 in funding to Syracuse University from August 1, 2023 to July 31, 2026 to conduct theoretical and computational research on rigidity and shape transitions in living and non-living materials. The key objectives of the research are to: 1) study rigidity and convexity in disordered fiber networks, 2) develop a continuum theory to...
This $400,000 federal Project Grant award from the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program supports a collaborative research project between Cornell University and Swiss partners to uncover the fundamental mechanistic principles that drive connective tissue morphogenesis and develop computational design tools to engineer architected biological tissues. The key products and services to be delivered under this 4-year award include: 1) developing...