Project Grant 2333820
- Federal Project Grant Award Summary The National Science Foundation's Division of Chemistry is awarding $749,999 to Princeton University and San Diego State University under the Mathematical and Physical Sciences program (CFDA 47.049) to develop an innovative method for dynamic cellular RNA imaging using metabolically incorporated fluorescent nucleosides. The project, which runs from September 1, 2025 through August 31, 2028, will advance live-cell RNA imaging from proof-of-concept to broad...
- Federal Grant Award Summary The Division of Chemistry within the National Science Foundation (NSF) awarded San Diego State University a $605,020 Project Grant beginning July 1, 2025, and concluding June 30, 2028, under the Mathematical and Physical Sciences program (CFDA 47.049). Professor Byron Purse and his research team are developing fluorescent nucleobase analogues (FBAs)—synthetic molecules designed to mimic natural genetic bases (adenine, cytosine, guanine, thymine, and uracil) in DNA and...
- The National Science Foundation (NSF) Division of Chemistry awarded a $1,500,000 Project Grant to Stanford University under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049). The grant, awarded on March 1, 2024, supports a 3-year research project titled "Evaluating and Advancing Cryo-EM for RNA Conformational Ensembles." The project aims to: (1) design, model, and experimentally probe RNA systems with discrete conformational states, and (2) characterize and challenge...
- The University of Kentucky Research Foundation was awarded a $780,000 Project Grant from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to develop new chemical tools to study protein function through metal-mediated ligand affinity chemistry. Principal Investigator Samuel G. Awuah and his research team will apply synthetic chemistry and molecular biology approaches to study reactions of specific amino acids...
- The National Science Foundation (NSF) Division of Chemistry awarded a $420,000 Project Grant to the University of Utah from August 1, 2023 to July 31, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The funding supports the development of a novel optical biosensor capable of detecting and quantifying a wide range of biological molecules, including biomarkers found in bodily fluids. The project leverages second harmonic generation (SHG) and optical heterodyning techniques...
- This $360,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The project aims to develop new peptide nucleic acid (PNA) molecules capable of selectively recognizing and binding to double-stranded non-coding RNA. This research addresses an important challenge in RNA biochemistry and could enable...
- This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
- This federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The $465,000 grant, awarded on August 15, 2024, focuses on developing new peptide nucleic acid (PNA) nucleobases capable of sequence-selective recognition of non-coding RNA. The research aims to uncover new methods for molecular...
- Federal Project Grant Award Summary The National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), awarded $510,000 to The Research Foundation For The State University Of New York (RF-SUNY) at the University at Albany, with funding obligated on September 1, 2025, through August 31, 2028. The award supports research led by Drs. Jia Sheng and Ting Wang to develop photoswitchable nucleotides—light-responsive nucleic acid building...
- This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...
This $180,330 Project Grant was awarded on June 15, 2023 by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences grant program (CFDA 47.049). The grant supports Dr. Edith Glazer at the University of Kentucky to develop a short RNA sequence, or aptamer, that can be observed in live cells using fluorescence microscopy. Specifically, the project aims to create an optimized pair of a luminescent ruthenium (Ru(II)) compound and an RNA aptamer that can track and quantify RNA levels or localization in cells, which is important for understanding RNA's role in regulating biological processes. The research combines synthetic chemistry, molecular biology, and microscopy techniques, and will provide training opportunities for undergraduate and graduate students, as well as integrate the work into an educational program to increase retention and success of underrepresented groups in chemistry.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $180.3k | 6/22/23 |