Project Grant 2516772
- This Project Grant award of $600,000 from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research by Dr. Read de Alaniz of the University of California, Santa Barbara (UCSB) to develop new photoresponsive molecular materials that change shape, color, and properties when exposed to visible light. The goal is to create water-compatible and stable "photoswitches" that can enable self-healing and actuation in solid materials,...
- The National Science Foundation (NSF) awarded a $600,000 project grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the Research Foundation of the City University of New York (RFCUNY) to support Professor Mahesh Lakshman's research on developing novel chemical methods for modifying nucleosides. Nucleosides are the fundamental building blocks of DNA and RNA, and this research aims to obtain a better understanding of chemical processes to enable selective modifications...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) is supporting a collaborative research project between Professor Michael Kienzler at the University of Connecticut and Professor Steven Lopez at Northeastern University. The researchers are studying the reactivity of molecular photoswitches and how ring strain can be used to control and enhance their photoswitching functions. The $260,096 project aims to develop cyclized...
- This Project Grant, awarded by the National Science Foundation's Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), provides $583,025 to Professors Shiyue Fang and Yinan Yuan of Michigan Technological University to develop new chemical technologies for the synthesis of long oligonucleotides (DNA and RNA segments). The research aims to overcome limitations of current biological methods and enable cost-effective production of long oligonucleotides essential for applications in...
- This Project Grant award from the National Science Foundation (NSF) under the CFDA 47.049 - Mathematical and Physical Sciences program supports a collaborative research effort between Professor Michael Kienzler at the University of Connecticut and Professor Steven Lopez at Northeastern University. The $271,019 award over the period of September 1, 2025 to August 31, 2028 is focused on studying the reactivity of molecular photoswitches by leveraging ring strain to enhance their photoswitching...
- This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
- The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal control...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences program (CFDA 47.049), has awarded a $749,999 Project Grant to Princeton University and San Diego State University. The grant will fund the development of a novel method for tracking the synthesis, localization, and dynamics of RNA messages in living cells using metabolically incorporated fluorescent nucleosides. This innovative approach will enable researchers to study the organization of cellular structures...
- This federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The $465,000 grant, awarded on August 15, 2024, focuses on developing new peptide nucleic acid (PNA) nucleobases capable of sequence-selective recognition of non-coding RNA. The research aims to uncover new methods for molecular...
- This $360,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The project aims to develop new peptide nucleic acid (PNA) molecules capable of selectively recognizing and binding to double-stranded non-coding RNA. This research addresses an important challenge in RNA biochemistry and could enable...
This $510,000 Project Grant awarded by the National Science Foundation's (CFDA 47.049 Mathematical and Physical Sciences) program provides funding to Dr. Jia Sheng and Dr. Ting Wang at the University at Albany, State University of New York (SUNY) to develop novel photoswitchable nucleotide building blocks and incorporate them into RNA oligonucleotides to control their structures and functions. The research aims to create light-responsive RNA molecules that can serve as photoswitchable regulators of gene expression or potential therapeutics, where the on/off state can be controlled non-invasively. The project will provide training in synthetic organic chemistry, physical chemistry, analytical chemistry, and nucleic acid chemistry, as well as skills in macromolecule X-ray crystallography and computational modeling, for graduate and undergraduate students. Additionally, the project is integrated with an outreach program to provide hands-on science experiences for K-12 students. This award runs from September 1, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $510.0k | 8/26/25 |