Project Grant 2427911

Award Date 8/15/24
Completion Date 7/31/27
Dollars Obligated $465K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Binghamton, NY 13902, USA
Similar Awards
This $360,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The project aims to develop new peptide nucleic acid (PNA) molecules capable of selectively recognizing and binding to double-stranded non-coding RNA. This research addresses an important challenge in RNA biochemistry and could enable...
This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...
This $300,000 Project Grant award from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) supports the development and experimental validation of computational tools for simulation-guided design of DNA nanostructures and molecular systems. The research goal is to integrate high-level kinetic models with low-level molecular dynamics models to create novel multiscale modeling frameworks for DNA nanotechnology. The project will also parameterize coarse-grained...
This $219,117 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will enable researchers at San Diego State University Foundation to investigate the role of RNA structure in the packaging and discovery of RNA bacteriophage genomes. The project aims to identify key RNA structures involved in the selective packaging of bacteriophage genomes, which could inform the design of synthetic capsids for RNA-based technologies. Additionally,...
The National Science Foundation awarded a $1,109,203 Project Grant to The Research Foundation For The State University Of New York to elucidate the role of protein arginine methylation in regulating RNA-binding protein function from May 2021 through April 2025. This award supports research under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing scientific knowledge and...
This $600,000 Project Grant award from the National Science Foundation's (NSF) Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), supports Professor Mahesh Lakshman and his research group at the City College of New York (CUNY) in developing novel chemical methods for modifying nucleosides. Nucleosides are the fundamental building blocks of DNA and RNA, and this research aims to expand the understanding of nucleoside reactivity and enable the creation of...
This Project Grant award for $658,000.00, funded by the National Science Foundation (NSF) through the Mathematical and Physical Sciences program (CFDA 47.049), supports research by Professor Hsin-Chih Yeh of the Department of Biomedical Engineering and Professor Devleena Samanta of the Department of Chemistry at the University of Texas at Austin. The goal of the project is to develop new types of molecular sensors comprised of functional nucleic acids (FNAs) that can detect and image chemicals...

This federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The $465,000 grant, awarded on August 15, 2024, focuses on developing new peptide nucleic acid (PNA) nucleobases capable of sequence-selective recognition of non-coding RNA. The research aims to uncover new methods for molecular recognition of biologically significant non-coding RNA, which plays important yet not fully understood roles in regulating biological processes. The project seeks to address the long-standing challenge of targeting double-stranded RNA and enable applications such as imaging and functional control of regulatory RNA, designer riboswitches for synthetic biology, and inhibition of biologically important RNA for fundamental studies. The grant also supports interdisciplinary collaborative research, training, and development of a diverse STEM workforce.

Generated 5/13/25, 4:03 AM