This $249,950 Project Grant award from the National Science Foundation's (NSF) Division of Materials Research (DMR) and Office of Multidisciplinary Activities (SBE/SMA) aims to develop new biomanufacturing methods for the scalable production and consistent characterization of extracellular vesicles (EVs). EVs are small particles released by cells that may have applications in drug delivery and disease treatment, but current manufacturing processes result in variable EV size and composition,...
The National Science Foundation awarded the University of Virginia a $133,333 project grant under the Engineering federal grant program (CFDA 47.041). The grant will fund a collaborative research project investigating the role of microenvironments, manufacturing processes, and metabolism on mesenchymal stromal cell production of extracellular vesicles. Specifically, the University will examine the effects of three-dimensional hydrogel microenvironments and manufacturing strategies on...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research focused on understanding the biogenesis, uptake, and cellular response to ribonucleoprotein (RNP) cargoes within extracellular vesicles (EVs). The $300,000 award to Vanderbilt University, effective March 1, 2024, will fund work to characterize the assembly of EV-associated RNP complexes and how they are delivered and act within recipient cells. The project utilizes the EV-CLASP...
This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...
This $304,951 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports the development of fibroblast-derived engineered extracellular vesicles (EVs) as a new nucleic acid therapeutic delivery system for peripheral nervous system (PNS) genetic disorders. The key objectives of this Small Business Technology Transfer (STTR) Phase I project are to optimize methods for EV isolation, purification, and cargo loading...
This National Science Foundation (NSF) Project Grant award, funded under the Engineering (CFDA 47.041) program, aims to develop a low-cost, mRNA-based manufacturing process for producing chimeric antigen receptor (CAR) T-cell therapies. The $250,000 award, effective May 1, 2025 through April 30, 2027, supports research to investigate protein expression and half-life in electroporated T-cells with mRNA, as well as the feasibility of using machine learning to create GMP-compliant...
The National Science Foundation (NSF) Office of Integrative Activities awarded a $738,400 Project Grant to the Morehouse School of Medicine (MSM) to investigate the synergistic effects of engineered extracellular vesicles (EVs) from stem cells and macrophages on angiogenesis, the formation of new blood vessels. The 4-year project will explore how EVs from different cell types cooperatively regulate normal and pathological angiogenesis, as well as develop novel EV-based therapeutic strategies....
This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), provides $503,000 to Harvey Mudd College to enhance understanding of extracellular vesicle biogenesis through substrate-associated signals. The research will interrogate factors influencing extracellular vesicle formation and selective cargo packaging in astrocytes. Engineered hydrogel substrates engaging integrins expressed by...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of extracellular vesicles (EVs) as therapeutic carriers. The $622,000 award, effective August 1, 2024 through July 31, 2027, will enable researchers at The Washington University in St. Louis to engineer endothelial cell-derived EVs to efficiently...
This $460,958 National Science Foundation Project Grant supports research and education activities focused on programmable cell-matrix interactions for regenerative engineering at Vanderbilt University from April 1, 2023 through March 31, 2028. The funding is provided through NSF's Engineering program under the Catalog of Federal Domestic Assistance number 47.041. Specifically, the grant will advance regenerative engineering approaches by developing a synthetic biology platform to enable...