This Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) aims to develop scalable manufacturing processes for engineered extracellular vesicles (EVs) that can serve as targeted drug delivery vehicles. The $2.55M grant to Vanderbilt University, awarded on January 1, 2024, will fund research to harness cellular processes for optimizing EV production, cargo loading, and cellular uptake. The long-term goal is to establish a biomanufacturing platform for...
The University of Georgia Research Foundation, Inc. received a $200,000 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The three-year award runs from June 2023 to May 2026 to investigate the role of microenvironment, manufacturing processes, and metabolism on mesenchymal stromal cell production of extracellular vesicles. Specifically, the University of Georgia Research...
The National Science Foundation (NSF) awarded a $250,000 Project Grant under the Social, Behavioral, and Economic Sciences (CFDA 47.075) program to the University of Alabama. The grant aims to develop new biomanufacturing methods to produce extracellular vesicles (EVs) accurately, consistently, and at scale. Specifically, the project will integrate flow filtration and size focusing techniques to address key challenges in EV production and characterization. This research will enable more...
This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), provides $503,000 to Harvey Mudd College to enhance understanding of extracellular vesicle biogenesis through substrate-associated signals. The research will interrogate factors influencing extracellular vesicle formation and selective cargo packaging in astrocytes. Engineered hydrogel substrates engaging integrins expressed by...
This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...
This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award to the University of Maryland, College Park (UMD) provides $671,681 in funding from July 1, 2025 to June 30, 2030. The project aims to advance the fundamental understanding of bacterial extracellular vesicle (BEV) biogenesis, fate, and function within the vaginal microbiome. Key objectives include characterizing BEV biogenesis, evaluating how the mucus barrier impacts BEV fate, and determining how BEV...
The National Science Foundation awarded a $125,000 Project Grant to the University of Virginia under the Engineering federal grant program (CFDA 47.041) for the period of September 1, 2021 through August 31, 2023. The grant funds research to develop high-throughput, autonomous real-time monitoring of tissue mechanical property changes using impedimetric sensor arrays. Specifically, the University of Virginia will work to advance monitoring capabilities for tissue engineering and mechanobiology...
This National Science Foundation Project Grant of $319,476 will fund research at the University of Virginia from March 2023 through February 2026 under the Engineering program (CFDA 47.041). The research aims to establish the foundational science for voxelated bioprinting through elucidating the nonlinear fluid dynamics of all-aqueous printing of viscoelastic droplets in yield-stress fluids. A printing platform will be developed to study droplet printing dynamics in real time. Control strategies...
This National Science Foundation (NSF) Engineering (CFDA 47.041) grant, awarded to the Rector & Visitors of the University of Virginia, aims to develop innovative, biology-inspired materials for purifying protein-based therapeutics. The $600,000 project will span 5 years, starting on February 1, 2025. Key objectives include: Designing mixed-mode peptide ligands to selectively adsorb and purify protein therapeutics from contaminants like viruses, unwanted proteins, and misformed products. The...
The National Science Foundation awarded a $466,266 project grant under the Engineering program (CFDA 47.041) to the University of Arkansas for work running from January 1st, 2022 through December 31st, 2023. The grant aims to develop new biophysical modulation approaches to improve the scalable biomanufacturing of stem cell-derived therapeutics. Specifically, the University of Arkansas and University of Oregon will test the effects of low-magnitude mechanical stimulation on mesenchymal stem...