Project Grant 2324378
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $350,000 to the University of Iowa to support research on the mechanisms involved in the propagation of chromosome fragments in the germline. The 3-year project aims to investigate how DNA breaks that occur during the formation of egg and sperm cells are stabilized and passed on to the next generation. The research will be conducted using the model organism C. elegans and will...
- This $795,135 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Illinois on protein dynamics under extreme environmental conditions. The four-year award beginning June 1, 2022 will fund three related subprojects investigating how proteins adapt to enable organism survival in stressful environments like heat, pressure and dehydration. The research will study intrinsically disordered protein structure and...
- The National Science Foundation (NSF) awarded a $955,876 Project Grant to Northwestern University to investigate the role of prion-mediated epigenetic regulation in the budding yeast, Saccharomyces cerevisiae. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to examine how two different yeast prions, [SWI+] and [MOT3+], interact and impact global transcription and protein homeostasis. Using advanced multi-omics techniques, the research program will identify...
- This $257,955 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research by Western Washington University (WWU) to investigate the biophysical principles that connect and lead to distinct aggregation and assembly pathways of intrinsically disordered proteins (IDPs). The project aims to understand how these dynamic and flexible proteins interact and self-assemble, bridging scales from the random motion of individual molecules...
- The University of Cincinnati was awarded an $851,499 National Science Foundation Project Grant under the Biological Sciences federal grant program (CFDA 47.074) for research titled "NSF-BSF: SYNERGISTIC MULTISCALE MODELING AND SINGLE-MOLECULE FLUORESCENCE STUDIES OF THE DYNAMICS AND FUNCTION OF AAA+ PROTEIN DISAGGREGATION MACHINES." The research will involve multiscale modeling and single-molecule fluorescence studies to examine the dynamics and function of AAA+ protein...
- The National Science Foundation (NSF), through its Integrative Activities program (CFDA 47.083), awarded a $300,000 project grant to the University of Mississippi to investigate the function of a broadly conserved bacterial protein and its role in pilus biogenesis. This 3-year project, spanning from February 2025 to January 2028, aims to characterize the mechanisms by which the unknown protein BRESU_2828 influences the synthesis of bacterial pili, which are structures used for attachment and...
- The National Science Foundation (NSF) awarded a $237,174 Project Grant under the Integrative Activities (CFDA 47.083) program to Middlebury College. The grant will fund a fellowship for an assistant professor and undergraduate student training to develop mathematical models describing the accumulation of healthy and pathological tau protein in brain cells, as seen in neurodegenerative diseases like Alzheimer's. The project aims to integrate the intracellular dynamics of tau accumulation with...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $2,282,500 to the University of Southern California (USC) to deepen the understanding of the molecules and mechanisms that drive protein aggregation. The research aims to explore the biological implications of disaggregases, which are enzymes that can both catalyze and inhibit protein aggregation, and how they may...
- This $414,390 National Science Foundation project grant supports research at Eastern Michigan University to advance understanding of autophagy, a cellular recycling and protection process. Funded under the NSF Biological Sciences program (CFDA 47.074), the three-year award beginning in February 2023 will investigate the molecular mechanisms that drive formation of the autophagosome, a vesicle that degrades cellular cargo. Researchers will study proteins involved in conjugating the ATG8 protein...
- This $217,701 federal Project Grant award from the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) aims to elucidate the role of liquid-liquid phase separation (LLPS) in the pathological aggregation of proteins associated with neurodegenerative diseases. The research, conducted by a multi-disciplinary US-France consortium, will employ computational and experimental techniques to gain novel insights into the protein conformations and...
The National Science Foundation (NSF) awarded a $245,000 Project Grant under the Integrative Activities program (CFDA 47.083) to The University of Iowa to study the role of amyloid aggregates in animal development and the function of a novel class of disaggregase proteins in regulating these aggregates. The project aims to characterize the presence and function of amyloid aggregates during early development and investigate how ABCF proteins, which have been shown to affect aggregation and disaggregation in yeast and animals, regulate these developmentally important aggregates. The research will leverage complementary experiments in C. elegans and S. cerevisiae to test the hypothesis that ABCF proteins act as novel disaggregases that control proteostasis and membrane-less organelle formation in a cell fate-specific manner. The project seeks to gain insights into aggregate-based pathologies and develop new strategies to leverage functional protein aggregates for regulating cell fate specification during development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $245.0k | 6/28/23 |