Project Grant 2323046
- This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems award of $234,000 to the University of Illinois will support collaborative research on developing an active lipid vesicle-based drug delivery system. The project aims to accomplish three key objectives: 1) examine the directed motion of lipid vesicles driven by encapsulated self-propelled particles, 2) develop a non-contact photoreaction mechanism to induce rupture and controlled...
- This National Science Foundation project grant of $500,000 will fund research at the University of California, Santa Barbara to study the assembly, disassembly, and mechanics of porous colloidal vesicles from April 15, 2023 to March 31, 2026. The research aims to advance understanding of fundamental processes involved in vesicle formation that are relevant across fields including physics, biology, engineering, and materials science. The university researchers will utilize state-of-the-art...
- The National Science Foundation (NSF) Division of Chemistry has awarded a 3-year, $450,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the University of California, San Diego (UCSD) to develop and characterize chemistries for generating dissipative phospholipid vesicles (liposomes) that exist in a non-equilibrium state and are sustained by chemical fuel sources. This work aims to better understand the molecular mechanisms underlying dynamic...
- The National Science Foundation Division of Materials Research awarded a $438,521 project grant to the Georgia Tech Research Corporation from July 1, 2021 to June 30, 2024. The grant supports research titled "Engineering Responsive Chemical Heterogeneity in Protein Vesicles for Simultaneous Delivery of Diverse Cargoes" under the Mathematical and Physical Sciences program (CFDA 47.049). The research aims to develop protein vesicle delivery systems that can encapsulate and release...
- This National Science Foundation (NSF) project grant under the Mathematical and Physical Sciences program (CFDA 47.049) will develop and characterize enzyme-loaded protein vesicles that can partition hydrophobic substrates and products to improve the sustainability of industrial biocatalysis. The $503,611 award to the Georgia Tech Research Corporation will (1) create pH-responsive vesicles containing a dehalogenase enzyme, (2) assess partitioning of substrates with varying hydrophobicity into...
- Superior Nano LLC received a $512,000 National Science Foundation Project Grant to develop dense nanolipid fluid systems for delivering drugs with poor bioavailability. The NSF funding supports research from June 2022 to May 2023 under the Technology, Innovation, and Partnerships program. This award will allow Superior Nano to advance scientific understanding of surfactant-lipid-water systems and create new knowledge applicable to manufacturing drug nanoparticles using twin-screw extrusion. By...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded Purdue University a $222,917 Project Grant under the Engineering federal grant program (CFDA 47.041) to support research titled "COLLABORATIVE RESEARCH: DYNAMICS AND STABILITY OF MULTI-COMPONENT LIPID VESICLES IN FLOW" from January 15, 2022 through December 31, 2024. The grant funding will support Purdue University's research exploring the dynamics and stability of...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $200,000 Project Grant to Lutheran University Association Inc., doing business as Valparaiso University, to develop a liposomal drug delivery platform for the treatment of lymphatic filariasis - a neglected tropical disease. The project aims to optimize the lymphatic uptake of existing lymphatic filariasis drugs and improve their efficacy against adult filarial worms. This will be achieved by synthesizing and...
- This National Science Foundation (NSF) Engineering Program project grant awarded to the Massachusetts Institute of Technology (MIT) provides $429,384 in funding to study how drug nanoparticles adhered to leukocyte (white blood cell) surfaces influence their mechanical properties and movement through microscale blood vessel networks. The 5-year research effort, from March 2024 to February 2029, will use a combination of biophysical models and microfluidic experiments to generate fundamental...
- The University of Illinois was awarded a $250,542 project grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems to conduct research on the dynamics and stability of multi-component lipid vesicles in flow. The grant falls under the NSF Directorate for Engineering's Engineering program (CFDA #47.041), which supports research and education to improve engineering. The University will use the funding over a two-year period ending...
The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $232,000 Project Grant to the President and Board of Trustees of Santa Clara College to develop an active lipid vesicle-based drug delivery system. The 3-year grant, starting on September 1, 2023, will leverage the encapsulation capacity of lipid vesicles to enclose both therapeutic payloads and self-propelled particles. This will enable the vesicles to undergo directed motion to targeted locations and undergo controlled release of the encapsulated payloads via light-induced reactions. The research aims to advance the fundamental understanding of the complex dynamics of lipid vesicles in these non-equilibrium processes, identifying key physical parameters and design principles to guide subsequent developments of active vesicle-based therapeutic delivery systems. No subawards are planned under this grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $232.0k | 8/25/23 |