Project Grant 2317442

Award Date 8/1/23
Completion Date 7/31/26
Dollars Obligated $651K
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Stanford, CA 94305, USA
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This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) provides $651,399 to The Leland Stanford Junior University (Stanford University) to investigate the biomechanical mechanisms conferring wound resilience in the single-celled organism Stentor coeruleus.

The key objectives of this 3-year project are to: 1) test the role of the cytoskeleton in conferring wound resistance to the cell, and 2) examine the role of large-scale mechanical force generation in complementing biochemical healing modes to close severe wounds. The research combines cell biology, microfluidics, and mechanobiology modeling to develop a molecular understanding of Stentor's robust wound repair capabilities. This research has the potential to enable engineering of new wound resilience functions in synthetic cells and soft micro-robots, improving their durability for industrial applications.

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