The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $139,341 project grant to the Regents of the University of California, San Francisco (UCSF) under the NSF Biological Sciences program (CFDA 47.074). The 3-year grant, effective August 1, 2023, supports collaborative research to investigate the biomechanical mechanisms underlying wound resilience in the single-celled organism Stentor coeruleus. The research will leverage cell biology, microfluidics, and...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) provides $651,399 to The Leland Stanford Junior University (Stanford University) to investigate the biomechanical mechanisms conferring wound resilience in the single-celled organism Stentor coeruleus. The key objectives of this 3-year project are to: 1) test the role of the cytoskeleton in conferring wound resistance to the...
This $635,000 Project Grant awarded by the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation supports research to understand how mechanical boundary conditions influence tissue assembly and repair in 3D fibrous microtissues. The research aims to advance knowledge about the mechanisms by which mechanical forces regulate new tissue formation and organization, particularly as it relates to wound healing. The project will integrate in vitro experiments and...
This Project Grant award of $285,570 from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) supports research at the University of Vermont & State Agricultural College investigating living tissues as new types of adaptive materials. The project aims to study how cellular adaptability influences the larger-scale mechanical behavior of tissues, connecting cellular biology and material properties. It will develop a new adaptive tissue model to integrate...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) is focused on understanding the physical factors that limit how individual cells and groups of cells respond to electric fields, and how this relates to wound healing. The $108,811 award to Princeton University, with a period of performance from August 15, 2024 to July 31, 2027, will support the development of computational models examining the motion of sensor molecules...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This three-year $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the molecular mechanisms governing cell membrane repair. Funded under the Biological Sciences program (CFDA 47.074), the grant aims to advance understanding of major problems in the biological sciences through basic research. Specifically, the principal investigator will conduct nonlinear surface spectroscopic investigations at Oregon State...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $123,956 Project Grant to New Mexico State University (NMSU) through the Biological Sciences program (CFDA 47.074) to support a 3-year research project. The project will probe the role of the small GTPase Rap1 protein in the mechanisms that drive morphogenesis - the changes in cell and tissue shape and arrangement during development. The goals are for the Principal Investigator to learn and apply...
This National Science Foundation Project Grant of $419,750 will fund research at Washington University in St. Louis from August 1, 2022 to July 31, 2025 to study how living cells move across dissimilar physical environments and retain mechanical memories of prior environments. Specifically, the award will integrate experiments and computational modeling to examine how forces generated by cells modify their surroundings in two mechanically different environments during migration. This will reveal...
This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...