This $616,151 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The research aims to improve the understanding of how tissues form, how embryos develop, and how diseases progress, with potential implications for advancements in tissue engineering and medicine. The 3-year project, set...
This $635,000 Project Grant awarded by the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation supports research to understand how mechanical boundary conditions influence tissue assembly and repair in 3D fibrous microtissues. The research aims to advance knowledge about the mechanisms by which mechanical forces regulate new tissue formation and organization, particularly as it relates to wound healing. The project will integrate in vitro experiments and...
This $300,000 project grant from the National Science Foundation will fund research at Cornell University from October 1, 2022 to September 30, 2025. The award is provided through NSF's Engineering Biology and Health Cluster within the Directorate for Engineering, Biological Sciences and Biotechnology, under the CFDA program for Engineering. Specifically, researchers at Cornell University and Washington State University will work to develop new tissue engineering strategies for cartilage repair....
This $500,000 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation supports research titled "GOALI/COLLABORATIVE RESEARCH: INSTABILITIES AND LOCAL STRAINS IN ENGINEERED CARTILAGE SCAFFOLD" being conducted at Cornell University from January 1, 2022 to December 31, 2024. The research aims to improve understanding of instabilities and local strains in engineered cartilage scaffolds, with the goal of enabling innovation in cartilage...
This National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences project grant for $300,000 aims to engineer shape-morphing materials as cell sheet culturing substrates to develop human tissues with controllable shape, cellular composition, and morphology. The 3-year project, beginning on September 1, 2023, will use thermoresponsive hydrogels to enable cell sheet expulsion and explore how material characteristics impact stem cell fate. Additionally, the project seeks...
This Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) provides $160,000 to support research at Boise State University focused on developing data-driven mechanomics approaches to understand how mechanical forces influence the behavior of certain stem cells that are critical for musculoskeletal tissue repair and regeneration. The primary objectives of this 3-year project are to: (1) create computational models to quantify intracellular...
This National Science Foundation (NSF) grant under the Integrative Activities (CFDA 47.083) program provides $285,570 to the University of Vermont & State Agricultural College to investigate the role of cellular adaptability in the mechanics and properties of living tissues as adaptive materials. The 5-year project will create computational models integrating biological and soft matter physics perspectives to understand how cellular adaptive behaviors influence phenomena like tissue jamming,...
This $314,769 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (CFDA 47.083) program supports research to advance the fundamental understanding of mechanobiological signaling in cells and tissues. The University of Delaware, a private research university, will develop innovative magnetic material platforms that can dynamically control local tissue stiffness to mimic various biological events. Through controlled experiments, the project aims to uncover the...
This $476,886 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at Boston University to develop computational models for predicting the spatiotemporal distribution of growth factors in tissue engineering scaffolds. The goal is to optimize scaffold designs to achieve optimal growth factor exposure profiles that improve tissue regeneration outcomes, particularly for cartilage repair. The research utilizes reaction-diffusion...
This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research to elucidate how the fluid-like properties of tissue extracellular matrices influence cell fate decisions in response to growth factors. The $480,237 grant, awarded to The Pennsylvania State University (Penn State) on August 1, 2024, will fund the development and characterization of viscoelastic materials to study the impact of matrix viscous dissipation on cell...