This Project Grant award from the National Science Foundation (NSF) Division of Emerging Frontiers, under the Biological Sciences program (CFDA 47.074), provides $388,992 to the University of Central Florida (UCF) to investigate the evolution of immune strategies across amphibian ontogeny. The key objectives are to: (1) use mathematical models and empirical data to predict when evolutionary history, pathogens, and environment favor T cell diversity within and among amphibian life stages; (2) quantify T cell receptor diversity for multiple frog species; and (3) experimentally manipulate frog diet and environment to assess developmental plasticity in T cell receptor diversity and infection outcomes. This interdisciplinary research integrates immunology, evolutionary biology, and mathematics to yield insights into the factors driving immune system maturation, plasticity, and diversity. The project will also provide training for early-career scientists and develop educational modules on the immune system through the lens of frog biology. No subawards are planned under this grant, which is active from Aug 15, 2023 to Jul 31, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $389.0k | 8/16/23 |