Project Grant 2147467
- This $240,000 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund a postdoctoral research fellowship to investigate the role of amphibian skin microbiomes in limiting the growth of deadly fungal pathogens. The research aims to explore the mechanisms by which certain skin microbes inhibit the fungal agents responsible for amphibian population declines, and to pilot the use of "antifungal probiotics" to protect...
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences Program (CFDA 47.074) is funding collaborative research led by Vanderbilt University to investigate how amphibian immune systems develop and adapt across life stages. The $274,765 project aims to: (1) use mathematical models and empirical data to understand how evolutionary history, pathogens, and environment influence T cell receptor diversity in frogs over ecological and evolutionary timescales; (2)...
- This $355,123 federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to genetically modify the immune system of the African clawed frog (Xenopus tropicalis) to improve its resistance to the deadly chytrid fungus. The goal is to identify how altering the frog's major histocompatibility complex (MHC) genes affects its ability to fight off this pathogen and survive infection. The project includes a sub-award to the University...
- This National Science Foundation (NSF) Project Grant award of $240,000, funded under the Biological Sciences program (CFDA 47.074), will support a 3-year postdoctoral research fellowship to investigate the history and evolution of the amphibian pathogen Batrachochytrium dendrobatidis (BD). The research aims to: Develop new genetic tools to selectively sequence DNA from BD and its amphibian hosts, even in highly contaminated and fragmented samples. Use these new genetic tools to genotype BD...
- This $945,365 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research on how habitat disruptions and fragmentation influence the skin microbiomes of amphibians and their ability to resist fungal infections. The primary objectives are to: 1) experimentally test the "adaptive microbiome principle" by exposing amphibians to varying microbial environments and fungal pathogens in controlled lab conditions, and 2)...
- The National Science Foundation awarded a $413,329 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of Colorado Boulder to support research integrating immune system and microbiome function during amphibian development from September 1, 2021 through August 31, 2024. The award will fund research examining how the immune system and microbiome interact and influence each other during amphibian growth and maturation. A subaward of $50,000 will support related...
- This $486,332 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a multi-year research effort at James Madison University (JMU) to characterize the metabolomes of bacteria associated with bats and identify antifungal molecules that could help protect bats against White-Nose Syndrome. The project leverages natural products chemistry, metabolomics, and synthetic microbial communities to understand how bacterial metabolites protect bats...
- The National Science Foundation (NSF) awarded a $494,261 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on frog skin evolution and adaptations. The project aims to: 1) quantify how frog skin has evolved over the past 200 million years in response to abiotic and biotic factors, 2) experimentally test the ability of anuran skin to decouple respiration and water loss, and 3) incorporate...
- This Project Grant award from the National Science Foundation (NSF) Division of Emerging Frontiers, under the Biological Sciences program (CFDA 47.074), provides $388,992 to the University of Central Florida (UCF) to investigate the evolution of immune strategies across amphibian ontogeny. The key objectives are to: (1) use mathematical models and empirical data to predict when evolutionary history, pathogens, and environment favor T cell diversity within and among amphibian life stages; (2)...
- This $391,336 National Science Foundation project grant funds research on linking host life history, movement ecology, and climate to predict disease outbreaks in tropical amphibian communities. The Division of Environmental Biology award supports a collaborative research effort between May 2022 and November 2023. Key products include field surveys of infection patterns in diverse amphibian populations across three tropical regions, an experimental manipulation of rainfall variability to test...
This $1,353,246 project grant from the National Science Foundation Division of Integrative Organismal Systems will fund research into the role of macrophages in amphibian skin antifungal defenses against the deadly chytrid fungus Batrachochytrium dendrobatidis (Bd) at Vanderbilt University Medical Center from August 1, 2022 to July 31, 2025. The research aims to define the interactions between frog macrophage subsets and Bd, examine the effects of Bd on interactions between frog macrophages and lymphocytes, and define cellular interactions in frog skin during Bd infection. This work supports the Biological Sciences program (CFDA 47.074) by strengthening understanding of major problems confronting the Nation such as emerging infectious diseases devastating biodiversity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $676.6k | 6/30/22 |