Project Grant 2310320
- The University of California, Davis (UC Davis) has been awarded a $300,000 EAGER (Early-concept Grants for Exploratory Research) grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences. The grant supports a project to investigate the use of CRISPR gene editing technology to separate closely linked beneficial and harmful traits in plants. Specifically, the project aims to determine whether eliminating certain DNA repair pathways, such as the Ku-dependent...
- The National Science Foundation (NSF) awarded a $800,000 Project Grant under its Biological Sciences program (CFDA 47.074) to The Regents of the University of California, doing business as University of California, Berkeley. The grant funding will support collaborative research to discover and characterize compact CRISPR gene editing systems that can be encoded in plant viruses. This will enable more efficient and widespread deployment of genome editing capabilities across a variety of crop...
- This $299,980 Project Grant from the National Science Foundation Division of Integrative Organismal Systems supports research into "METHODS FOR CHROMATIN PROFILING OF PLANT GAMETES AND ZYGOTES" at the University of California, Davis from September 1, 2021 through August 31, 2022. The award falls under the Biological Sciences (47.074) program, which aims to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing knowledge of major...
- This $725,512 project grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop highly efficient and robust prime editing systems in rice, tomato, and poplar plants. Prime editing is an advanced CRISPR/Cas gene editing technology that enables precise gene modifications, offering significant advantages over conventional CRISPR approaches. The project will optimize prime editor proteins, improve prime editor guide RNA structures and...
- This Project Grant award, funded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), aims to develop new biotechnology for accelerating crop improvement through an intragenic genome engineering approach. The research seeks to adjust, combine, and transfer desired DNA elements sourced from the same plant species to improve crop traits such as grain yield and disease resistance, which can be adopted faster than traditional transgenic crop development approaches. The...
- The National Science Foundation awarded a $307,400 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Missouri System to develop epigenetic editing tools for improving crop plants. The project aims to expand the capabilities of genome editing by enabling targeted changes in gene expression, rather than just DNA sequence, to generate novel traits in important crops like rice and tomato. Key objectives include adapting the epigenetic editing approach...
- This $1,211,545 Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) will support the development of advanced Prime Editing (PE) systems in rice, tomato, and poplar plants. Prime Editing is a novel and highly versatile CRISPR-based gene editing technology that enables precise genome modifications. The key objectives of this 3-year project are to optimize Prime Editor proteins to increase their activity and editing efficiency, improve pegRNA structure and...
- This $322,020 Project Grant award from the National Science Foundation's (NSF) Division of Integrative Organismal Systems will support collaborative research at the University of California, Davis (UC Davis) to develop improved methods for CRISPR/Cas9-based gene editing in maize. The key objectives are to generate maize lines expressing high levels of Cas9 nuclease and to engineer and optimize viral vectors to efficiently deliver guide RNAs for both somatic and heritable gene editing. This...
- This federal Project Grant award of $1,192,499.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research by the Donald Danforth Plant Science Center in Missouri to develop epigenetic editing tools for crop improvement. The key objectives of this 4-year project are to: 1) Expand epigenetic editing technologies to other crop species beyond cassava, such as rice and tomato, to enable disease resistance; 2) Demonstrate additional applications of...
- This Project Grant award, titled "EAGER: TRTECH-PGR: LEVERAGING DNA ADP-RIBOSYLATION FOR GENE EDITING IN PLANTS", is funded by the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $299,932. The award was made on July 15, 2025 with a target completion date of June 30, 2027. The primary objectives of this project are to improve the efficiency of a recently developed bacterial genome editing tool in two model plant species, tobacco and...
This Project Grant from the National Science Foundation Division of Integrative Organismal Systems, under the Biological Sciences federal grant program (CFDA 47.074), provides $298,102 to the University of California, Davis for research entitled "EAGER: Targeted and Specific Elimination of Plant Chromosomes." The two-year award beginning April 1, 2023 supports development of new genome editing techniques using CRISPR to enable targeted elimination of specific plant chromosomes at scale. This has potential applications for accelerating crop breeding through haploid induction, manipulation of polyploid crop genomes, and selection of desired haplotypic configurations. The research aims to demonstrate and optimize chromosome elimination in Arabidopsis and tomato, with the goal of engineering elimination of a complete parental chromosome set in tomato to induce haploidy. Outcomes will further the Biological Sciences program's goals of increasing biological knowledge and strengthening the national scientific enterprise.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $298.1k | 1/31/23 |