This Project Grant award, funded by the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074), will support the development and optimization of a novel protein degradation tool called E3-DART (E3-Targeted Degradation of Plant Proteins) for plant cell biology research. The $337,667 award to North Carolina State University aims to: Develop a ligand-inducible E3-DART system to enable chemically-controlled protein degradation in plants. Combine E3-DART with other...
This $322,978 National Science Foundation (NSF) project grant, awarded under the Biological Sciences (CFDA 47.074) program, aims to enhance the capabilities of the E3-DART protein degradation system for use in plant cell biology research. The key products and services to be delivered include: Developing a ligand-inducible E3-DART system to provide chemically-controlled protein degradation in plant cells. Creating novel recombinant tools to precisely control E3-DART activity. Demonstrating...
This $300,000 Project Grant awarded by the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) supports research to develop novel methods for genetically modifying plants using the parasitic plant Cuscuta campestris, also known as dodder. The key goals are to 1) stably transform the dodder plant to enable host gene editing, 2) create a dodder protoplast system for rapid screening of gene editing constructs, and 3) develop a dodder-mediated gene editing system....
This $725,512 project grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop highly efficient and robust prime editing systems in rice, tomato, and poplar plants. Prime editing is an advanced CRISPR/Cas gene editing technology that enables precise gene modifications, offering significant advantages over conventional CRISPR approaches. The project will optimize prime editor proteins, improve prime editor guide RNA structures and...
This federal Project Grant award of $1,192,499.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research by the Donald Danforth Plant Science Center in Missouri to develop epigenetic editing tools for crop improvement. The key objectives of this 4-year project are to: 1) Expand epigenetic editing technologies to other crop species beyond cassava, such as rice and tomato, to enable disease resistance; 2) Demonstrate additional applications of...
The National Science Foundation awarded a $307,400 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Missouri System to develop epigenetic editing tools for improving crop plants. The project aims to expand the capabilities of genome editing by enabling targeted changes in gene expression, rather than just DNA sequence, to generate novel traits in important crops like rice and tomato. Key objectives include adapting the epigenetic editing approach...
The University of California, Davis (UC Davis) has been awarded a $300,000 EAGER (Early-concept Grants for Exploratory Research) grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences. The grant supports a project to investigate the use of CRISPR gene editing technology to separate closely linked beneficial and harmful traits in plants. Specifically, the project aims to determine whether eliminating certain DNA repair pathways, such as the Ku-dependent...
The National Science Foundation (NSF) awarded a $800,000 Project Grant under its Biological Sciences program (CFDA 47.074) to The Regents of the University of California, doing business as University of California, Berkeley. The grant funding will support collaborative research to discover and characterize compact CRISPR gene editing systems that can be encoded in plant viruses. This will enable more efficient and widespread deployment of genome editing capabilities across a variety of crop...
This $1,211,545 Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) will support the development of advanced Prime Editing (PE) systems in rice, tomato, and poplar plants. Prime Editing is a novel and highly versatile CRISPR-based gene editing technology that enables precise genome modifications. The key objectives of this 3-year project are to optimize Prime Editor proteins to increase their activity and editing efficiency, improve pegRNA structure and...
This federal Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) provides $250,000 to Virginia Polytechnic Institute & State University (Virginia Tech) to develop novel methods of plant genome editing enabled by the parasitic plant Cuscuta campestris (dodder). The key objectives of this 3-year project are to: 1) achieve stable transformation of dodder to enable host gene editing, 2) develop a dodder protoplast system for rapid screening of gene...