This federal Project Grant award, totaling $349,074, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program. The grant supports research to develop and apply 13C-enhanced nuclear magnetic resonance (NMR) spectroscopy methods to study the structure and function of lysine acetylation, a ubiquitous protein post-translational modification. The key products and services to be delivered include: 1)...
This $899,894 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (IA) program, CFDA 47.083, will support research to characterize the structure, membrane topology, substrate specificity, and biochemical properties of a unique mitochondrial HAD phosphatase enzyme in a divergent unicellular organism. The project aims to elucidate the dual functional roles of this enzyme, which may provide insights into the broader cellular functions of the related TIM50 protein...
This $461,575 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Earlham College to investigate how a bacterial enzyme, ProXP-X, recognizes and distinguishes between L- and D-amino acids, and how it protects bacterial cells from D-amino acid toxicity. The key goals are to characterize how ProXP-X binds and identifies its targets, and determine if its activity prevents D-amino acid toxicity in living bacteria. The...
This National Science Foundation (NSF) Integrative Activities Program grant award of $453,612 to Xavier University of Louisiana supports research to develop new synthetic methods for creating dimeric quinone molecules with potential applications in energy storage, pharmaceuticals, and dyes. The project, led by Principal Investigators Jayalakshmi Sridhar and Kevin Riley, aims to standardize a straightforward approach for producing a variety of homo- and heterodimeric quinones. The key...
This Project Grant award, valued at $776,309.00, is funded by the Molecular Biophysics Cluster in the Division of Molecular and Cellular Biosciences of the National Science Foundation (CFDA 47.074 Biological Sciences). The project aims to push the boundaries of current technologies to explore the structural responses to chemical modifications that trigger the release of RNA polymerase II from pausing and its entry into efficient decoding of genetic information. Specifically, the investigator...
This $574,915 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports research by Professor Monika Raj of Emory University to develop new chemical probes and strategies for detecting and studying modifications to the amino acid histidine in proteins. The goal is to create novel chemical probes capable of selectively labeling modified histidine residues in proteins and capturing the...
This $149,999 Project Grant award from the National Science Foundation's Integrative Activities (CFDA 47.083) program will support a collaborative research effort to model X-chromosome inactivation in human cells. The principal investigators from New York University, Harvard University, and the New Mexico Consortium will leverage expertise in molecular biology, genomics, computational biology, biophysics, and biomolecular modeling to investigate the complex genome organization and epigenetic...
This federal Project Grant award of $899,982 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a collaborative research effort to study X-chromosome inactivation and genome organization in human cells. The research team from New York University, Harvard University, and the New Mexico Consortium will integrate advanced genomics data, computational modeling, and biophysical approaches to unravel the complex folding of the X-chromosome and its impact on...
This $600,019 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research effort led by New York University (NYU) to investigate the structure and function of the X chromosome, with a focus on the process of X-chromosome inactivation. The research team, which also includes researchers from Harvard University and the New Mexico Consortium, will integrate high-resolution genomics data with advanced spatial modeling to...
This Project Grant award of $550,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Iowa State University to investigate how different histone writer enzymes coordinate to regulate gene expression and chromatin structure. The project will explore how the histone modifications H3K9me2, H3S10ph, and H4K16ac work together to fine-tune gene expression levels by controlling chromatin accessibility. Experiments will utilize Drosophila larval...