Project Grant 2306190
Award Date
7/1/23
Completion Date
6/30/27
Dollars Obligated
$741K
Federal Agency
Division of Molecular and Cellular Biosciences
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $360,100 to The Regents of the University of California, San Francisco (UCSF) to develop novel photoacid-binding proteins and study proton dynamics in biological systems. The goal is to elucidate mechanisms of proton transfer, which is critical for biological energy transduction, using computational protein design and...
The Regents of the University of California, San Francisco received a three-year, $374,994 Project Grant from the National Science Foundation Division of Chemistry. The grant supports collaborative research titled "De Novo Protein Constructs for Photosynthetic Energy Transduction" under the Mathematical and Physical Sciences program (CFDA 47.049).
The research aims to advance understanding of major problems in photosynthesis through increasing the store of scientific knowledge on de...
The National Science Foundation (NSF) awarded a $626,831 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Milwaukee (UWM) to conduct collaborative research on the molecular mechanisms behind how certain bacteria use light-sensing proteins called phytochromes to regulate essential developmental processes. The project aims to use advanced structural biology techniques like cryo-electron microscopy and time-resolved X-ray crystallography to study...
The National Science Foundation (NSF) awarded a $1,000,000 Project Grant under the Biological Sciences (CFDA 47.074) program to The Regents of the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally designed de novo protein components. The goal is to develop synthetic membrane signaling systems capable of programmable receptor clustering, tunable signal amplification, and bidirectional transmembrane signaling. This...
This $199,276 National Science Foundation project grant supports research into mapping and comparing the link between protein scaffolds and quantum events in thermally activated enzymes and flavin-based photoreceptors. Funded under the Biological Sciences program (CFDA 47.074), the four-year award to the University of California, Merced aims to advance understanding of how biological macromolecules are able to efficiently promote and utilize non-trivial quantum phenomena necessary for...
This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
This $118,904 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research by the University of California, San Francisco (UCSF) to reveal signal transduction mechanisms through protein design. The key objectives are to:
Use protein design to generate and tune sensor domains in bacterial histidine kinases, enabling insight into how sensor stability affects signaling output.
Employ de...
This $904,987 NSF Project Grant award, under the Biological Sciences program (CFDA 47.074), supports collaborative research between the University of California, Berkeley and partners in Switzerland to investigate the fundamental mechanisms underlying the biogenesis and organization of thylakoid membranes in green algae. The research aims to develop a mechanistic model of how these complex membrane structures that house the photosynthetic machinery are built and populated with proteins. By...
This $369,297 Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports research at San Francisco State University to develop a synthetic transhydrogenation module to enhance biosynthesis of valuable chemicals.
The key objectives are to: 1) elucidate the structural mechanisms underlying autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism, 2) leverage this understanding to engineer...
This National Science Foundation Project Grant of $921,054 supports research to develop new biological functions through engineering plant hormone receptors. Led by the Regents of the University of California, Riverside under the Biological Sciences program (CFDA 47.074), the project engineers plant sensors to recognize pharmaceuticals and dietary molecules. It then uses these sensors to design "sentinel cells" that indicate molecule presence through color changes. Specifically, the...