Project Grant 2428204

Award Date 1/1/25
Completion Date 12/31/27
Dollars Obligated $369K
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94132, USA
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  1. Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts stationary phase biosynthesis.

  2. Apply this knowledge to engineer the GltAB-GudB system and explore alternative transhydrogenase enzymes to boost the biosynthesis of compounds limited by redox imbalance, such as free fatty acids and shikimate.

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