This $429,999 federal Project Grant was awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) to The Regents of the University of California, San Francisco (UCSF) to conduct proof-of-concept experiments to determine the feasibility of implanting microelectronic chips into living cells. The goal is to develop a method for adding new functional connections to the signaling networks inside cells, allowing for better understanding and reprogramming of cellular...
The National Science Foundation (NSF) awarded a $599,999 Project Grant to the University of Southern California (USC) under the Computer and Information Science and Engineering (CFDA #47.070) federal grant program. The grant supports research and graduate student training focused on modeling, optimization, and analysis of biologically-inspired microbial community networks. Key areas of investigation include understanding the phenomenon of quorum sensing, which enables collective behaviors in...
This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
This three-year, $782,602 National Science Foundation project grant supports the development of a 3D bionic network interface to enable bidirectional communication with cells and tissues at the biotic-abiotic interface. Funded under NSF's Engineering program (CFDA 47.041), the University of North Carolina at Chapel Hill will design and test a multi-modality platform integrating biosensing and stimulation at the microscale to form a closed-loop network facilitating holistic integration and...
This $375,000 project grant from the National Science Foundation's Division of Computing and Communication Foundations, under the Computer and Information Science and Engineering program (CFDA 47.070), will support the development of hybrid cell-semiconducting polymer systems for high-density biological data storage at William Marsh Rice University. Over the two-year period from August 2022 to July 2025, the university researchers will work to encode 100 bytes of information into synthetic RNA...
This three-year, $376,264 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to develop new genetically engineered biological circuits and sensors. The University of Colorado Boulder team, led by The Regents of the University of Colorado, aims to harness plant hormone receptors to rapidly design genetic circuits controlled by user-specified ligands. They will engineer novel plant-derived chemical sensors that can recognize...
This $450,000 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to The Johns Hopkins University supports the development of a new "dual-series gate" organic electrochemical transistor (DS-OECT) biosensor technology. The key objectives include material synthesis, device fabrication, computer modeling, and biological fluid analysis to create a highly sensitive and stable sensor capable of reliably detecting protein biomarkers for various...
The National Science Foundation (NSF) awarded a $376,301 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of Rochester. The grant, titled "CAREER: Programmable Microbial Community Composition and Function Using Plasmid Conjugation," aims to develop an innovative platform that leverages horizontal gene transfer to self-regulate and stabilize microbial consortia. The project seeks to overcome challenges in controlling the balance of bacterial species...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) provides $550,000 to The Research Foundation for the State University of New York (RF SUNY) to develop innovative 3D-printed microbial fuel cells (micro-MFCs) with integrated electronics for sustainable on-chip power sources. The key objectives are to: 1) establish standardized microfabrication techniques for the novel micro-MFCs with programmable biotic-abiotic electrodes, 2) characterize...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $647,750 Project Grant to Princeton University under the Biological Sciences grant program (CFDA 47.074) to develop a closed-loop control system for regulating microbial communities. The project aims to integrate optogenetic controls and metabolite biosensing to dynamically modulate the composition and productivity of synthetic microbial communities for the production of valuable chemicals. The...
This $375,000 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports the development of redox-based bioelectronics through the Semisynbio-III award to the University of Maryland, College Park. The three-year project will advance four technological areas to create communicating microbial cells and decision-making cells that can be instructed by electric inputs to perform logic operations by writing to genomes or adjusting consortium populations. Researchers will fabricate biocompatible thin film materials to transduce electrode-imposed redox signals into biologically-recognized signals and enable communication between native biological signaling modalities and quorum sensing. Systems-level modeling will establish metrics for efficient energy and information flow through electroassembled bio-electronic networks. Subawards of $125,000 each to the University of Wisconsin-Madison and Georgia Tech will support complementary work integrating these components into biohybrid devices opening communication between biological and abiotic systems.