The University of Southern California was awarded a $1,859,227 project grant from the National Science Foundation Division of Emerging Frontiers under the Biological Sciences federal grant program (CFDA 47.074). The grant will fund collaborative research to define the rules governing microbiome interactions critical for providing key ecosystem functions using a model diazotroph community. The research is expected to advance scientific understanding of major problems in biology over a four year...
The University of Southern California was awarded a $2,500,651 project grant from the National Science Foundation Division of Emerging Frontiers under the Biological Sciences federal grant program (CFDA 47.074). The grant will support research from January 1, 2022 to December 31, 2026 to develop machine learning, systems modeling, and experimental approaches to understand the universal rules of life of microbiota using marine time series data. The Biological Sciences program aims to promote...
The National Science Foundation (NSF) awarded a $376,301 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of Rochester. The grant, titled "CAREER: Programmable Microbial Community Composition and Function Using Plasmid Conjugation," aims to develop an innovative platform that leverages horizontal gene transfer to self-regulate and stabilize microbial consortia. The project seeks to overcome challenges in controlling the balance of bacterial species...
The National Science Foundation (NSF) awarded a $949,877 Project Grant to Rutgers, The State University through the Biological Sciences (CFDA 47.074) program. The grant funds a collaborative research project to develop closed-loop control systems that integrate optogenetics and metabolite biosensing to modulate the composition and productivity of synthetic microbial communities. The project aims to advance basic research in this area and generate strategies for improved production of...
The University of Southern California was awarded a three-year, $750,000 Project Grant from the National Science Foundation Division of Computing and Communication Foundations under the Computer and Information Science and Engineering federal grant program (CFDA 47.070). The grant will support the development of quantitative network analytics from pre-launch through post-operation phases. Specifically, the University will synthesize approaches for analyzing complex network dynamics and behaviors...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $647,750 Project Grant to Princeton University under the Biological Sciences grant program (CFDA 47.074) to develop a closed-loop control system for regulating microbial communities. The project aims to integrate optogenetic controls and metabolite biosensing to dynamically modulate the composition and productivity of synthetic microbial communities for the production of valuable chemicals. The...
The University of California Irvine (UC Irvine) received a $765,540 Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences program (CFDA 47.074) to investigate how the spatial arrangement of microbial cells affects the ecosystem process of denitrification. The research will use evolutionary algorithms and 3D printing to construct and analyze pre-defined spatial communities of bacteria capable of performing different steps of the...
The National Science Foundation (NSF) awarded a $552,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the University of Nevada, Reno (UNR). The 3-year grant, starting on August 1, 2023, supports research led by Professor Tal-Gan to study the interplay between different bacterial communication pathways in Streptococcus mutans. The project aims to characterize how diverse quorum sensing circuits within the same bacterial species affect one another and...
The National Science Foundation (NSF) awarded a $200,055 Project Grant under the Biological Sciences (CFDA 47.074) program to Purdue University. The grant funding supports a 5-year research project focused on studying the assembly and supramolecular organization of bacterial microcompartments. This research aims to develop a model for how these large protein assemblies are built, mature, and function, with the goal of understanding the mechanisms of both beneficial and pathogenic...
This three-year, $673,000 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research into the role of ecological interactions in diversification among coexisting microbial species. The University of California, Irvine will study how commensal interactions, where one species benefits while the other is unaffected, influence the formation of new bacterial species in microbial communities. Researchers will culture bacteria in a commensal...
The National Science Foundation (NSF) awarded a $599,999 Project Grant to the University of Southern California (USC) under the Computer and Information Science and Engineering (CFDA #47.070) federal grant program. The grant supports research and graduate student training focused on modeling, optimization, and analysis of biologically-inspired microbial community networks. Key areas of investigation include understanding the phenomenon of quorum sensing, which enables collective behaviors in bacterial populations. The project seeks to leverage communications, signal processing, and decision-making methods to further elucidate these microbial interactions and their potential applications in domains such as bioremediation, plant growth promotion, and infection suppression. While no significant experimental work is proposed, the research will leverage prior microbial data from existing collaborations to drive the modeling and analytical approaches. The project aims to ultimately inform the design of engineered systems inspired by the underlying biological principles.