Project Grant 2221192
- This National Science Foundation Project Grant of $138,000 will fund research into understanding the influence of hormone signaling in reptile reproductive development from March 1, 2023 to February 28, 2025. The grantee will leverage CRISPR gene manipulation techniques in brown anole lizards to generate estrogen and androgen receptor mutant animals. Morphological, 3D imaging, immunohistochemistry, and genomic methods will then assess anatomical and physiological differences between wild-type...
- This National Science Foundation project grant of $771,071 awarded on March 1, 2023 will fund research into the role of extracellular RNA (exRNA) in intercellular and interkingdom communication through February 28, 2027. The award is part of the Biological Sciences program under the CFDA number 47.074, which supports basic biological research to strengthen the Nation's scientific enterprise and increase knowledge of major problems. Specifically, a collaborative team of seven laboratories at...
- This $980,133 Project Grant awarded by the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) funds fundamental research into the genetic basis of gonad determination in Anolis lizards through May 1, 2026 to April 30, 2030. The University of Georgia Research Foundation, Inc. will conduct molecular and cellular biology research to investigate the Y-linked RPL6Y gene and its role in testis development, utilizing advanced...
- This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), provides $503,000 to Harvey Mudd College to enhance understanding of extracellular vesicle biogenesis through substrate-associated signals. The research will interrogate factors influencing extracellular vesicle formation and selective cargo packaging in astrocytes. Engineered hydrogel substrates engaging integrins expressed by...
- This National Science Foundation Project Grant of $249,999 awarded on June 1, 2022 will support research at New York University to develop an exosome-based lipoproteoplex for small interfering RNA delivery. The research team will engineer a protein-exosome system to encapsulate siRNA into exosomes at high efficiency and promote endosomal escape and delivery with a favorable safety profile. As part of the Mathematical and Physical Sciences program, this award will also support education and...
- This National Science Foundation (NSF) Project Grant under CFDA Number 47.041 - Engineering provides $360,000 in funding to Cornell University from July 1, 2023 to June 30, 2026 to develop a novel biosensing platform for the simultaneous detection and quantification of exosomes (small vesicles released from cells) and their molecular cargo. The key objectives are to: (1) develop methods to capture, quantify, and profile exosomes using a plasmonic biosensor; (2) develop techniques to lyse the...
- This $274,218.64 Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke to Brandeis University will support research into the mechanisms underlying exosome release from neurons. The grant aims to determine how exosomes are generated from the endosomal system in neurons and explore neuronal exosome and endosome biology in an animal model. The grantee will manipulate the ESCRT and MUNC13-4/RAB11 pathways to investigate endosomal dynamics...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Scripps College a $923,538 Project Grant under the Biological Sciences program (CFDA 47.074) from July 15, 2021 through June 30, 2025. The grant funds research into the role of the haploidizer gene in genome elimination by a selfish B chromosome. The Biological Sciences program aims to advance the field and strengthen the national scientific enterprise through basic biological research. This award supports...
- This National Science Foundation (NSF) Biological Sciences project grant, awarded to Worcester Polytechnic Institute (WPI), aims to better understand the role of trophoblast cells and extracellular vesicles (exosomes) in placental function and development. The $502,999 award, effective June 15, 2024 through May 31, 2027, will focus on two key objectives: 1) characterizing how oxygen levels and biochemical factors influence trophoblast invasion of the extracellular matrix, and 2) examining how...
- This Project Grant from the National Science Foundation's Division of Integrative Organismal Systems provides $193,086 to Saint Norbert College Inc. from June 2021 through May 2025 for collaborative research on targeted neurosteroidogenesis and complex memory function. The award supports research under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increasing knowledge and...
This National Science Foundation award under the Biological Sciences program (CFDA 47.074) provides $260,819 to Rollins College from July 2022 through June 2024 to test the role of exosomes in regulating steroidogenesis. Specifically, the grantee will determine if exosomes originating from endocrine cells carry biochemical information to initiate local steroid hormone production in non-endocrine organs of an anolis lizard model. The research aims to establish if local steroidogenesis increases exosome secretion, confirm if exosomes contain steroidogenic enzyme mRNA, and use a new agent to block exosome secretion and assess impact on local steroidogenesis. If exosomes transfer mRNA between tissues to regulate physiology and behavior, it will significantly advance understanding of cell-to-cell communication with implications across biology. The award also supports scientific training for undergraduate students, including those from underrepresented groups.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $260.8k | 7/14/22 |