Project Grant 2203664
- This National Science Foundation (NSF) Project Grant under CFDA Number 47.041 - Engineering provides $360,000 in funding to Cornell University from July 1, 2023 to June 30, 2026 to develop a novel biosensing platform for the simultaneous detection and quantification of exosomes (small vesicles released from cells) and their molecular cargo. The key objectives are to: (1) develop methods to capture, quantify, and profile exosomes using a plasmonic biosensor; (2) develop techniques to lyse the...
- This $457,390 Project Grant award from the National Science Foundation's (NSF) Division of Materials Research aims to develop a new mRNA delivery system based on functional phosphoserine (PS) lipids. The award will support research to understand the targeted and immunomodulatory properties of these zwitterionic functional materials for mRNA delivery, with potential applications in gene therapy, protein-replacement therapy, and cancer immunotherapy. Key objectives include enhancing mRNA...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) provides $600,000 in funding to New York University (NYU) researchers Dr. Oded Regev and Dr. Jef Boeke to develop a novel experimental method called "PolySnap-Seq" to probe the collective organization of ribosomes along individual RNA molecules. The research aims to gain novel insights into ribosome behavior and enable new biotechnology...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $448,250 to develop sulfonium lipid nanoparticles (SLNPs) as a novel platform for mRNA delivery. The project aims to expand the chemical diversity of sulfonium lipids, investigate their unique physicochemical and biological properties, and explore the therapeutic potential of organ-targeting mRNA/SLNP formulations...
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $522,131.00 to New York University (NYU) from August 1, 2023 to July 31, 2026. The funded research aims to understand the relationship between RNA sequence features and splicing outcomes, as well as the role that nuclear speckles play in RNA splicing decisions. The project will leverage high-throughput assays and interpretable machine learning to identify sequence-encoded...
- This $150,620 CAREER award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program supports research to develop improved methods for delivering genome-editing proteins to diseased cells. The award, which runs from March 1, 2025 to February 28, 2030, will apply machine learning and polymer science to understand how the properties of polymer-based delivery vehicles impact their ability to transport different genome-editing proteins into diverse cell types. The...
- This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $375,633 to the University of Nevada, Las Vegas (UNLV) to develop an enhanced lipid nanoparticle (LNP) platform for selective and improved in vivo delivery. The goal is to gain a better understanding of how incorporating endogenous ligands into LNPs impacts their physicochemical and biochemical properties, with a focus on improving...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $695,000 in funding to Case Western Reserve University to investigate the structural implications and cellular behavior of DNA-based nanoparticles for therapeutic drug or gene delivery. The research project aims to understand how the shape, design, and other features of synthetic DNA nanoparticles impact their ability to interact with a cell's protein machinery and facilitate the production...
- This $3,000,000 project grant, awarded by the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program, aims to solve the long-standing challenge of developing self-amplifying ribonucleic acid (SARNA) technologies. The project, led by Trustees of Boston University, a private non-profit research university, will: Synthesize a diverse library of modified nucleoside triphosphates (ModNTPs) and use them to produce modified SARNA with extended cellular half-life. Evaluate the...
This National Science Foundation Project Grant of $249,999 awarded on June 1, 2022 will support research at New York University to develop an exosome-based lipoproteoplex for small interfering RNA delivery. The research team will engineer a protein-exosome system to encapsulate siRNA into exosomes at high efficiency and promote endosomal escape and delivery with a favorable safety profile. As part of the Mathematical and Physical Sciences program, this award will also support education and outreach activities including virtual research experiences for high school and undergraduate students to democratize access and train the next generation of scientists. New York University will serve as the primary awardee with research conducted at their New York City campus through the projected completion date of May 31, 2025.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $250.0k | 5/20/22 |