This $1,555,035 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will fund research into the discovery of novel functional RNA classes through computational integration of massively-parallel RBP binding and structure data. The award was made under the Biological Sciences federal grant program (CFDA 47.074) to support basic biological research strengthening the nation's scientific enterprise. The California Institute of Technology will use the...
This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
The California Institute of Technology (Caltech) received a $672,155 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences on November 15, 2021 to complete the project by October 31, 2024. The grant falls under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increasing knowledge and understanding of major problems. Specifically,...
The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
The University of California, San Diego will collaborate on research integrating theory and experiment to unravel protein transport in the endoplasmic reticulum under a $551,789 project grant from the National Science Foundation. The grant was awarded January 15, 2021 under the Biological Sciences program (CFDA 47.074) to further the progress of the biological sciences and enhance understanding of major problems confronting the nation. Over a three-year period ending December 31, 2024, UC San...
The National Science Foundation (NSF) awarded a $299,529 Project Grant to the University of California, San Diego (UCSD) under the Biological Sciences program (CFDA 47.074) to develop novel "LOC-SEQ" technologies for genome-wide screening of factors affecting mRNA localization. This research aims to bridge the gap between identifying spatially localized RNAs and understanding the mechanisms directing their localization, initially focusing on mitochondrial localization in yeast and...
This $586,230 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a fundamental understanding of the physical organization and molecular transport mechanisms of the protective "glycocalyx" shield that covers mammalian cell surfaces. The research will use a combination of computational modeling, engineered cell surface systems, and live cell experiments to quantify how factors like protein glycosylation,...
The National Science Foundation awarded a $138,000 Project Grant to support research titled "Understanding Protein Synthesis in Energetically Constrained Microbial Consortia" from September 1, 2021 through August 31, 2023. The grant was awarded under the Biological Sciences program (CFDA 47.074) to further the program's goals of advancing the biological sciences and strengthening the scientific enterprise through increased knowledge and understanding of major issues facing the...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $590,000 Project Grant to the University of California Irvine (UC Irvine) on August 15, 2023 under the Biological Sciences program (CFDA 47.074). The goal of this 3-year research project is to develop novel strategies for real-time metabolite sensing and metabolite-induced enzyme localization that can contribute to fundamental cellular knowledge and improve the efficiency of synthetic biology...
The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...