Project Grant 2243705

Award Date 3/15/23
Completion Date 2/29/28
Dollars Obligated $1.6M
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Pasadena, CA 91125, USA
Similar Awards
This Project Grant from the National Science Foundation Division of Emerging Frontiers, under the Biological Sciences federal grant program (CFDA 47.074), provides $932,563 to support research into the discovery of novel functional RNA classes through computational integration of massively parallel RNA-binding protein binding and structure data. The President and Fellows of Harvard College will utilize highly multiplexed approaches to generate transcriptome-wide measurements of hundreds of...
This $469,407 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will fund research to discover novel functional RNA classes through computational integration of massively parallel RNA-binding protein binding and structure data. The awardee, Georgia Tech Research Corporation, will conduct this research from March 2023 through February 2028. Specifically, the organization will...
This $1,042,995 National Science Foundation project grant, awarded on March 15, 2023 under the Biological Sciences (47.074) program, funds research at Oregon State University and Mount Holyoke College to discover novel functional RNA classes through computational integration of massively parallel RNA-binding protein binding and structure data. The grantees will develop new experimental and computational methods to systematically identify unknown non-coding RNA classes by combining known and...
This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant titled "TRANSITIONS: EVOLVING OUR UNDERSTANDING OF DYNAMIC RNA FOLDING AND FUNCTION" to Northwestern University under the Biological Sciences grant program (CFDA 47.074). The objective of this 3-year award is to uncover fundamental principles linking RNA sequence to dynamic RNA folding processes and function in biological systems. The research aims to enhance the...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
This federal Project Grant award, valued at $382,801 and awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to develop a new class of artificial RNA-based condensates as customizable organelles for use in living cells. The key objectives are: Optimizing the sequence and structure of RNA "nanostars" to produce condensates with tailored thermodynamic and biophysical properties, as well as...
This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...

This $1,555,035 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will fund research into the discovery of novel functional RNA classes through computational integration of massively-parallel RBP binding and structure data. The award was made under the Biological Sciences federal grant program (CFDA 47.074) to support basic biological research strengthening the nation's scientific enterprise.

The California Institute of Technology will use the funding to develop novel experimental and computational methods to systematically identify new classes of non-coding RNAs in the human transcriptome. Researchers will generate transcriptome-wide measurements of RNA-protein interactions across hundreds of RNA binding proteins to uncover conserved sequence and structural motifs specific to novel RNA classes. They will also assess the phylogeny of identified classes in an unprecedented comprehensive effort to discover and characterize "dark matter" RNAs whose functions remain unknown. Project results will be made accessible through an online database to further scientific knowledge of RNA biology.

Generated 1/6/24, 4:36 PM