Project Grant 2218507
- This Project Grant award of $876,272.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund collaborative research to develop advanced genetic manipulation tools for bacteria. The project aims to expand the biotechnological capabilities of marine bacteria called Vibrios, which are important in food production, disease, and host-microbe interactions. The research will focus on scaling up methods to influence the expression of individual bacterial genes...
- This $1,500,004.00 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) to the J. David Gladstone Institutes supports research to investigate the mechanisms of a novel bacterial immune system called retrons. Retrons sense when a bacterial cell is infected by a virus (phage) and respond by killing the infected cell to protect the larger bacterial population. The key focus of this 3-year project (8/1/2025 - 7/31/2028) is to uncover the...
- This three-year, $240,000 project grant from the National Science Foundation's Division of Biological Infrastructure will fund research and outreach activities under the Biological Sciences program (CFDA 47.074). The fellow will conduct a comprehensive survey of bacterial and viral communities in a parasitic plant system to identify horizontal gene transfer events. Microbial interaction networks will be analyzed to understand patterns of gene sharing. Workshops and activities will be developed...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- This National Science Foundation (NSF) federal Project Grant award under the Biological Sciences program (CFDA 47.074) is funding the University of Illinois to construct a new type of self-replicating synthetic cell system. The $448,355 award from June 1, 2024 to May 31, 2027 supports the development of engineered synthetic cells that can grow, divide, and replicate their genetic information using nucleic acids as both structural and genetic components. The project aims to investigate the...
- This Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $2,379,217 to the Donald Danforth Plant Science Center from March 1, 2022 to February 28, 2025. The grant supports research to develop targeted DNA integration techniques in plants. Specifically, the Center and its sub-awardees—the University of South Carolina Aiken Campus and University of Missouri—will work to engineer hyperactive versions of the Pong transposase proteins and...
- The Cold Spring Harbor Laboratory will provide a two-week intensive Synthetic Biology Summer Course from August 2022 through July 2025 under a $515,458 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences. The course aims to introduce scientists to synthetic biology through a combination of practical lectures, open-ended research projects, and seminars led by field experts. Participants will gain hands-on experience with techniques such as cell-free...
- This three-year, $321,668 Project Grant from the National Science Foundation's Division of Emerging Frontiers will fund research into the impact of horizontal gene transfer on genetic evolution in bacteria. Awarded to Yale University on February 1, 2022 and set to be completed by January 31, 2025, this grant supports work under the Biological Sciences program (CFDA 47.074). Specifically, the grant will further the biological sciences and understanding of major problems by funding three aims....
- This $1,373,044 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the Massachusetts Institute of Technology to develop microbial strains with minimal genomes for integrated bioprocessing using supercritical carbon dioxide. The goal is to elucidate the genotype-phenotype relationship of tolerance to supercritical CO2 for a selected microorganism and construct a reduced genome strain displaying the desired tolerance phenotype....
- This three-year, $409,923 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports the development of genomic algorithms and statistical models to study natural gene transfer in transformable bacteria at the University of Wisconsin-Madison. The university will collaborate with partners to generate genome-scale statistical algorithms and computational tools for analyzing molecular and biological drivers of gene transfer events during natural...
This three-year, $2,050,512 National Science Foundation project grant supports research to develop genome transplantation techniques for non-mycoplasma bacteria species. The goal is to remove technical barriers limiting the construction of synthetic cells and establish rules for transplanting isolated synthetic bacterial genomes to produce cells with designed properties. The J. Craig Venter Institute will investigate the mechanism of genome transplantation, develop the technique for at least two non-mycoplasma species, and use microfluidics to automate and improve efficiency. This work directly addresses the NSF Biological Sciences program's objectives to advance biological knowledge and strengthen the scientific enterprise by facilitating training and discussions on synthetic biology applications across academia, industry and the public. Completing on May 31, 2025, the project's outcomes could significantly expand the field of synthetic biology cell design.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 6/7/22 |