Project Grant 2509382
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $479,999 Project Grant to The Johns Hopkins University to explore the interactions between CRISPR-Cas systems and temperate bacteriophages. The 5-year research project, starting on March 1, 2025, aims to investigate how CRISPR-Cas systems, which protect bacteria from viral infections, can exploit the life cycle of temperate phages to acquire new memories. The findings are expected to inform...
- This Project Grant award of $440,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on two key research areas: Developing a quantitative understanding of the processes involved when contractile injection systems (e.g. phage tails, tailocins, Type VI secretion systems) breach bacterial cell envelopes. This knowledge will be applied to the design and retargeting of R-type pyocins...
- This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
- This Project Grant award of $876,272.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund collaborative research to develop advanced genetic manipulation tools for bacteria. The project aims to expand the biotechnological capabilities of marine bacteria called Vibrios, which are important in food production, disease, and host-microbe interactions. The research will focus on scaling up methods to influence the expression of individual bacterial genes...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 will fund a 3-year postdoctoral fellowship to research the adaptive response of bacteria to bacteriophage infection and high hydrostatic pressure. The fellow will develop novel fluorescence microscopy techniques to quantify bacterial growth, cell size, and morphology under these environmental stressors using model organisms E. coli, P. aeruginosa, and S. piezotolerans. The project...
- This federal Project Grant award of $801,000.00 from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program supports research at the University of Rhode Island (URI) to investigate how bacteria use toxin-antitoxin systems to survive environmental stress, viral infection, and antibiotic exposure. The key objectives of the project are to: 1) identify how protein maintenance factors like chaperones and proteases regulate the activation of bacterial toxins by removing...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award, totaling $1,117,922.00, supports research to determine the mechanisms of bacterial tyrosine kinase activation and regulation. The Research Foundation of the City University of New York will utilize computational and experimental methods, including biochemical assays, NMR spectroscopy, and mass spectrometry, to investigate the activation of bacterial BY-kinases in both Gram-positive and Gram-negative...
- This federal Project Grant award of $1,000,000.00 from the National Science Foundation's Biological Sciences program (CFDA 47.074) was provided to The Trustees of Princeton University to study "Quorum Sensing Across Scales and Between Domains". The project aims to investigate bacterial communication processes, known as quorum sensing, to better understand how bacteria can synchronize behavior and potentially control harmful pathogens or promote beneficial bacteria. Key objectives...
- This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports a research project at Bryn Mawr College focused on understanding the molecular mechanisms of phospholipid trafficking in bacterial cell membranes. The $368,978 award, with a performance period from August 15, 2025 to July 31, 2028, will engage student-scientists in interdisciplinary research at the interface of biochemistry, biology, and molecular biophysics. The project...
- This National Science Foundation (NSF) Project Grant award, funded under the Integrative Activities program (CFDA 47.083), supports research on the structural mechanisms of bacterial extracellular DNA-recognition. The $216,149 award to the Board of Regents of the University of Nebraska, from July 1, 2023 to June 30, 2026, aims to identify and characterize novel DNA receptor subunits incorporated into bacterial surface appendages. The project will purify soluble protein constructs, measure...
This $1,500,004.00 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) to the J. David Gladstone Institutes supports research to investigate the mechanisms of a novel bacterial immune system called retrons. Retrons sense when a bacterial cell is infected by a virus (phage) and respond by killing the infected cell to protect the larger bacterial population. The key focus of this 3-year project (8/1/2025 - 7/31/2028) is to uncover the precise mechanisms of how this novel type of retron system, which differs from the canonical retron mechanism, provides defense against a range of phages. The research will utilize genetic experiments, biochemistry, phage assays, and sequencing to elucidate these mechanisms. Additionally, the project aims to develop molecular technologies based on retron components for genome engineering and make them accessible across diverse bacterial species. The award also includes providing summer laboratory experiences for community college students seeking to transfer to 4-year universities to pursue degrees in science and engineering.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 8/14/25 |