The National Science Foundation (NSF) awarded a $568,480 Project Grant under the Engineering (CFDA 47.041) program to The Regents of the University of Colorado, doing business as the University of Colorado, to conduct research on a novel biosensing concept for high-sensitivity measurement of cell mechanical biomarkers. The 3-year award, effective May 1, 2024, will investigate how biological cells with different mechanical properties interact with acoustic waves propagating along a substrate, and...
This National Science Foundation (NSF) CAREER program Project Grant award for $242,687 supports the development of an ultrasensitive nanopore biosensor technology for point-of-care detection and quantification of multiple infectious disease biomarkers. The award, under NSF's Engineering program (CFDA 47.041), aims to create a next-generation nanopore sensing platform that can achieve sub-femtomolar detection limits, enabling rapid and accurate diagnosis of infectious diseases at the point of...
This $1,200,000 Project Grant awarded by the National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) will support the development of innovative sensing technologies that integrate DNA nanotechnology and CMOS electronics to enable more frequent blood and urine testing for early disease detection. The 4-year project aims to: Develop molecular engineering techniques using DNA origami nanotechnology to perform in-situ signal amplification for...
The National Science Foundation awarded the University of Louisville a $358,793 project grant under the Biological Sciences program (CFDA 47.074) to develop a microfluidic platform for dielectric characterization of biological nanoparticles. A team of graduate, undergraduate, and high school students will design and build the system using microfabrication techniques, gaining entrepreneurial training through university programs. The specialized platform will enable fundamental insight into...
This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...
The National Science Foundation awarded $473,318 under the Engineering (47.041) federal grant program to the University of Denver from October 2022 through October 2026. The Project Grant funding will support research into developing multiplexed biomedical sensor systems for automated diagnosis using machine learning algorithms. Specifically, the university will investigate plexcimonic structures for ultrasensitive, simultaneous detection of multiple biomarkers. It will also develop algorithms...
The National Science Foundation (NSF) Division of Chemistry awarded a $420,000 Project Grant to the University of Utah from August 1, 2023 to July 31, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The funding supports the development of a novel optical biosensor capable of detecting and quantifying a wide range of biological molecules, including biomarkers found in bodily fluids. The project leverages second harmonic generation (SHG) and optical heterodyning techniques...
The National Science Foundation (NSF) awarded a $299,712 Project Grant under the Integrative Activities (CFDA 47.083) program to the University of South Carolina to develop and characterize electrochemical aptamer-based (E-AB) sensors for rapid, multi-analyte detection of cardiovascular disease (CVD) biomarkers. The project aims to integrate carbon-based electrode arrays with nano-sized designs and advanced aptamer technology to enhance the stability and performance of E-AB sensors compared to...
The National Science Foundation (NSF), under its Engineering program (CFDA 47.041), awarded a $429,832 Project Grant to the University of Massachusetts (UMass) to develop a novel method for rapid and sensitive detection of nucleic acids such as DNA and RNA. The main objectives of the 5-year project are to: Determine the nanomechanoelectrical transduction principle of nucleic-acid nanostructures tethered to a graphene transistor and oscillating in an electric field. Achieve rapid,...
This three-year, $376,264 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to develop new genetically engineered biological circuits and sensors. The University of Colorado Boulder team, led by The Regents of the University of Colorado, aims to harness plant hormone receptors to rapidly design genetic circuits controlled by user-specified ligands. They will engineer novel plant-derived chemical sensors that can recognize...