This three-year $484,222 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research at the University of Colorado Boulder to develop a mesoscale kinetic theory framework for early mitotic spindle organization. The research team will combine biophysical experiments, computational modeling, and statistical analysis to build understanding of how spindle formation is affected by interactions between diverse protein...
The National Science Foundation awarded New York University a $120,000 Project Grant under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to develop a mathematical model of mitosis. The award period is from June 15, 2022 to May 31, 2026.
Under the award, NYU will build on previous work modeling cell division to create a more realistic simulation of closed mitosis. Researchers will extend their model to include a deformable elastic nuclear envelope integrating the...
This National Science Foundation Project Grant of $673,524 supports research at North Carolina State University to develop a mathematical model of mitosis through the Biological Sciences program (CFDA 47.074). The model will simulate chromosome segregation and nuclear envelope shape change coordination in fission yeast mitosis. Researchers will extend an existing mitosis model to include a deformable elastic nuclear envelope integrating the spindle, chromosomes, and nuclear envelope. They...
This National Science Foundation award provides $1,656,474 to the University of Colorado Boulder through May 2026 to develop mathematical models of mitosis under the Biological Sciences grant program (CFDA 47.074). The university will build on previous work modeling chromosome segregation during cell division to create a new model integrating deformable nuclear envelope dynamics. Researchers aim to identify how forces within the nuclear envelope drive successful chromosome separation during...
This federal Project Grant award for $185,000 was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program. The grant supports research by Rensselaer Polytechnic Institute (RPI) to investigate the spatial-temporal regulation of the cell cycle transition from G1 to S phase, known as "START", in the model organism budding yeast. The research aims to reveal the fundamental molecular mechanisms underlying the orchestration of...
This four-year, $1.388 million project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research between New York University and other organizations to discover the principles of active self-organization in the differentiating genome. The research will integrate state-of-the-art live cell experiments with multiscale mathematical and computational models of chromatin dynamics in the cell nucleus. Experiments will...
This National Science Foundation (NSF) Project Grant, awarded under the Mathematical and Physical Sciences (CFDA 47.049) program, provides $106,915 to North Carolina State University (NC State) over a 5-year period from April 2024 to March 2029. The grant supports computational and theoretical investigations into the mechanisms and dynamics of the actin cytoskeleton, which is critical for cellular processes like growth, migration, and force generation. The research aims to elucidate key...
This Project Grant award of $408,368 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Missouri System to examine the molecular mechanisms that orient cell divisions within tissues of the model organism Drosophila melanogaster. The research aims to resolve how a conserved set of proteins, including the microtubule motor dynein, localize to control the pulling force that aligns the mitotic spindle during cell division....
This $380,000 Project Grant was awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports a joint experiment-theory project focused on developing a new generation of computational models to study eukaryotic cell motility, with a specific emphasis on how cells utilize "blebbing" and nuclear deformation to move through complex geometries. The project brings together researchers from...
The National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences awarded a $399,755 Project Grant to the University of California, Santa Barbara (UCSB) under the Mathematical and Physical Sciences program (CFDA 47.049). The grant funds the development of new mathematical modeling paradigms and simulation software tools for investigating cell mechanics across multiple scales. This includes contributions from cell membranes and the cytoskeleton, and the roles of...