This four-year, $1,486,812 National Science Foundation project grant supports research to advance understanding of the evolution and function of Y chromosomes in mammals. The grant funds the University of California, Riverside to produce Y chromosome assemblies and multi-tissue transcriptomes for eight rodent species, using long read sequencing and optical mapping. Gene expression atlases will be generated from long and short read transcriptomics including single cell sequencing. The research...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program will provide $765,480 over 5 years to the Regents of the University of California at Riverside to conduct research on the genetic and evolutionary drivers of recombination rate variation. The research will leverage threespine sticklebacks and Drosophila fruit flies as model systems to test long-standing hypotheses about recombination rate...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences (CFDA 47.074) federal grant program provides $240,000 in funding from January 1, 2025 to December 31, 2027 to conduct research on the evolutionary dynamics of recombination landscapes and adaptive trait architectures across varying degrees of gene flow. The key research objectives are to: (1) generate multiple linkage maps to examine recombination rate as an individual-level phenotype, (2) conduct a...
This five-year Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $647,360 to Mississippi State University to investigate the evolutionary advantages of genetic recombination. The grant supports research from June 2022 through May 2027 that aims to integrate theoretical and empirical approaches to uncover how recombination influences evolution. As part of its goal to promote progress in the biological sciences and strengthen the national...
This $600,019 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research effort led by New York University (NYU) to investigate the structure and function of the X chromosome, with a focus on the process of X-chromosome inactivation. The research team, which also includes researchers from Harvard University and the New Mexico Consortium, will integrate high-resolution genomics data with advanced spatial modeling to...
This Project Grant from the National Science Foundation will fund $240,000 over three years to support a postdoctoral research fellowship in biology under the Biological Sciences program (CFDA 47.074). The fellowship will fund integrative research investigating the interaction of genomes, environments, and phenotypes in driving the diversification of North American lizards during adaptive radiation. The fellow will generate reference genomes for Anolis lizards, apply cytogenetic techniques to...
This $1.165 million National Science Foundation project grant will fund research at Marquette University from September 2022 through August 2026 to identify sex chromosomes in understudied lizard and snake species. The research aims to advance understanding of sex chromosome evolution by investigating reptile groups with diverse sex determination systems. Researchers will characterize sex chromosomes through comparative genomics, transcriptomics, and phylogenetics analyses. They will also...
This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program will fund research to investigate the evolution of DNA replication timing in great apes, including humans and chimpanzees. The $406,525 award to Health Research, Inc. will measure DNA replication progression across chromosomes, identify differences, and link variations in replication timing to factors like mutation rates, gene expression, and the evolution of new traits. The research aims to...
This $3.2 million project grant from the National Science Foundation's Division of Integrative Organismal Systems and Biological Sciences program (CFDA 47.074) supports research at Cornell University to elucidate the meiotic recombination landscape in maize and develop the ability to modify it. The goals are to examine how chromatin, DNA sequence, and genetic diversity impact recombination hotspots; understand how recombination landscapes evolve; and test methods to create artificial hotspots. A...