Project Grant R35GM154837

Award Date 9/1/24
Completion Date 6/30/29
Dollars Obligated $383K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Riverside, CA 92521, USA
Similar Awards
This $395,000 five-year project grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate the contribution of structural variants, such as chromosomal rearrangements, to trait variation and adaptive evolution in three insect systems: Timema stick insects, Callosobruchus maculatus seed beetles, and Lycaeides butterflies. The research will combine genome assemblies, population...
This Project Grant award of $240,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) will fund a postdoctoral research fellowship to investigate the evolutionary dynamics of recombination landscapes and adaptive trait architectures across varying degrees of gene flow. The research will leverage genomic tools, common garden experiments, and evolutionary simulations using the Atlantic silverside fish as a model organism. Key outcomes will include multiple...
This Project Grant award of $375,430 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the evolutionary and genomic drivers of mutation spectra. The goal is to explain diverse patterns of spontaneous mutation by connecting evolutionary causes and consequences with molecular mechanisms. The key products and services to be delivered under this five-year grant include:...
This $787,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at the University of California, Riverside to investigate the roles of nuclear RNA modifications in gene regulation. The 5-year project seeks to study three key types of nuclear RNA modifications - RNA polyphosphatases, the m2,2,7G cap, and m5C on piRNAs - and how they regulate mRNA, lincRNA, DNA replication,...
The National Institute of General Medical Sciences (NIGMS) awarded a $616,786 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, San Francisco (UCSF). The grant will fund research that aims to uncover how evolutionary forces shape patterns of genetic variation and drive phenotypic variation across diverse human populations. Key focus areas include investigating the effects of recessive deleterious alleles and...
This $276,000 National Science Foundation project grant supports research and training in evolutionary genomics of rapid adaptation in wild threespine stickleback fish populations. Funded under the Biological Sciences program of the NSF Division of Biological Infrastructure, the award enables a postdoctoral fellow to study how genomic and population factors impact rapid adaptive evolution in the wild. Using threespine stickleback that diverged from marine to freshwater populations within the...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $246,424 supports research to define how human cells control the initiation and early steps of recombination at DNA double strand breaks. The project leverages novel methods to understand how cells choose different DNA repair mechanisms, with a focus on recombination, which maintains encoded genetic information. The research will address key questions around recombination activation, the role of the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will provide $380,495.00 to the Regents of the University of Michigan to conduct research on germline mutagenesis at recombination hotspots over a 5-year period from February 1, 2025 to January 31, 2030. The research aims to address the mechanisms and factors that promote aberrant repair at meiotic double-strand breaks, which can...
This federal Project Grant award for $380,725 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to establish a molecular model for how viral receptor-binding proteins (RBPs) evolve new functions. The key research objectives are to: Test a proposed two-step molecular model for how RBPs gain new function, using high-throughput gene editing and phenotyping assays. Examine protein characteristics that...
This five-year Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $647,360 to Mississippi State University to investigate the evolutionary advantages of genetic recombination. The grant supports research from June 2022 through May 2027 that aims to integrate theoretical and empirical approaches to uncover how recombination influences evolution. As part of its goal to promote progress in the biological sciences and strengthen the national...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) in the amount of $382,958 will support a 5-year research program at the University of California, Riverside (UC Riverside) to study the genetic and evolutionary causes and consequences of recombination rate variation.

The key objectives of this research are to explore the evolutionary drivers of recombination rate variation in threespine sticklebacks, perform experimental tests on the role of structural variants and chromosomal inversions in determining recombination rate, and develop new statistical methods for comparing recombination maps. This work aims to advance the fundamental understanding of meiotic recombination and its wide-ranging impacts on genetic inheritance, adaptation, and speciation. The research program will leverage expertise across genomics, computational biology, and evolutionary biology, while also training personnel in cutting-edge techniques applicable to various domains of biology.

Generated 7/1/25, 4:30 AM