This $1,100,000 Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) to President and Fellows of Harvard College aims to advance the understanding of plasmid evolution within bacterial cells. The research will develop novel experimental tools and techniques to precisely measure intracellular plasmid competition and investigate the mechanisms and evolutionary dynamics of these important mobile genetic elements. The project will also create educational...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 will fund a 3-year postdoctoral fellowship to research the adaptive response of bacteria to bacteriophage infection and high hydrostatic pressure. The fellow will develop novel fluorescence microscopy techniques to quantify bacterial growth, cell size, and morphology under these environmental stressors using model organisms E. coli, P. aeruginosa, and S. piezotolerans. The project...
The National Science Foundation (NSF) has awarded a $240,000 Project Grant under the Biological Sciences program (CFDA 47.074) to support a 3-year NSF Postdoctoral Research Fellowship in Biology. The fellowship will fund research and training focused on investigating the process of horizontal gene transfer (HGT) in bacterial communities. The research aims to create a detailed map of how mutations in specific plasmid genes impact a plasmid's ability to spread horizontally between bacteria, as...
The National Science Foundation (NSF) awarded a $802,161 Project Grant to the University of Massachusetts Medical School (UMass Medical) to study the structural mechanisms of bacteriophage (phage) infection and assembly. This 3-year grant, effective June 1, 2024, aims to advance the understanding of virus-host interactions, promote the development of effective antiviral strategies, and leverage phage-related applications. The research will focus on three aspects of the phage life cycle: virus...
The National Institute of General Medical Sciences (NIGMS) awarded a $967,980 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to President and Fellows of Harvard College (Harvard Medical School) to conduct research on the evolutionary tradeoffs in antibiotic resistance. The project will explore various aspects of plasmids, horizontal gene transfer, and their interactions with resistance genes and bacteriophage, as well as investigate the evolution of antibiotic resistance...
The National Science Foundation awarded a $514,999 Project Grant to the President and Fellows of Harvard College from February 15, 2021 through January 31, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds collaborative research to design a minimized genome cyanobacterial chassis for efficient bioproduction. The Biological Sciences program aims to promote advancement in the biological sciences and strengthen the national scientific enterprise through increasing...
This two-year National Science Foundation project grant of $138,000 supports postdoctoral fellowship research titled "Phage Life History and Evolution as a Driver of Microbial Ecology." The grant was awarded September 1, 2021 under the Biological Sciences program (CFDA 47.074) to conduct basic research promoting advancement in the biological sciences. The fellowship will investigate how bacteriophage life cycles and evolution influence microbial community structure through...
This three-year, $321,668 Project Grant from the National Science Foundation's Division of Emerging Frontiers will fund research into the impact of horizontal gene transfer on genetic evolution in bacteria. Awarded to Yale University on February 1, 2022 and set to be completed by January 31, 2025, this grant supports work under the Biological Sciences program (CFDA 47.074). Specifically, the grant will further the biological sciences and understanding of major problems by funding three aims....
This Project Grant award, valued at $173,030 and funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support the development of a novel assay for receptor-guided discovery of environmental bacteriophages (phages). The research team at President and Fellows of Harvard College aims to create a generalizable co-culture assay that can differentiate phages based on their infection dependencies,...
The National Science Foundation awarded a two-year, $138,000 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to conduct research characterizing the genetic mechanisms of bacteria-phage coevolution in Listeria and Salmonella. The postdoctoral fellow will analyze the dynamic relationships between the foodborne pathogens Listeria monocytogenes and Salmonella enterica, and their bacteriophages. Through serial passaging experiments and whole genome sequencing, the...