Project Grant 2134999
- The University of Illinois was awarded a $1.5 million Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Engineering (47.041) federal grant program. The four-year award will support the RECODE project to develop synergistic genetic and microenvironmental engineering platforms for directed liver organoid differentiation. The University will apply engineering approaches to generate functional liver organoids for downstream applications...
- This $1.5 million Project Grant from the National Science Foundation (NSF), under the Engineering federal grant program (CFDA 47.041), will fund research at the University of California Irvine from October 2022 through September 2026. The university will develop hydrogel-based bioengineering technologies to reproducibly generate distinct spatial organization and cellular diversity within cortical organoids, mimicking the development of different brain regions. Researchers will leverage expertise...
- This $1,383,800 federal Project Grant award from the Department of Health and Human Services' National Institutes of Health, under the Trans-NIH Research Support (CFDA 93.310) program, supports the University of Pittsburgh's research to develop new methods for creating and testing developmental signaling patterns. The project aims to leverage high-throughput optogenetic manipulation to build libraries of paired data on developmental signaling patterns and resulting tissue structures. This...
- The National Science Foundation awarded a $138,000 Project Grant to support research activities from November 1, 2021 to October 31, 2023 under the Biological Sciences program (CFDA 47.074). The grant funding will enable the grantee to conduct research at the University of Pittsburgh aimed at furthering understanding of the evolution of gene regulatory networks through empirical and theoretical approaches. The Biological Sciences program seeks to advance the field and strengthen the national...
- This $750,000 Project Grant award, funded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074), supports the development of manufacturable 3D mammalian cell culture systems with integrated sensing technologies, focusing on neural organoids. The key objectives are to: (1) build and test conformal microelectrode arrays to interrogate neural organoids and transition them to flexible electronics manufacturing; and (2) develop photonic-based sensors to detect small...
- This $325,044 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to develop a new "aerodynamic fiber deposition" technology to manufacture biomimetic soft fiber-reinforced composites with spatially varying fiber arrangements. The research aims to enable the production of high-throughput, highly controlled nano/microfiber patterns that mimic the complex fiber structures found in biological tissues like skin, muscle, and...
- The University of Pittsburgh has been awarded a $438,137 Project Grant from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to develop a microfluidic technology to model the interactions between macrophages and epithelial cells in a 3D environment under hypoxic conditions. The goal is to advance the fundamental understanding of how oxygen levels impact key cellular processes in macrophages, such as migration and proinflammatory cytokine production. This research will also...
- The National Science Foundation awarded a $138,000 Project Grant to support research titled "Translating Transcriptome to Phenome: Defining Intercellular Signaling Landscapes of the Liver" from March 1, 2022 to February 29, 2024. The grant was awarded under the Biological Sciences program (CFDA #47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increased knowledge and understanding of major problems. Funding...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded The Johns Hopkins University a $1,999,508 Project Grant titled "EFRI BEGIN OI: Bringing Reward to Embodied Organoid Intelligence" on August 1, 2025. This grant seeks to advance the emerging field of Organoid Intelligence (OI) by incorporating reward-based learning mechanisms into brain organoids to enable more complex and adaptive behaviors and increase training efficiency. The research team will connect...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $1,958,603 project grant to the University of California, Santa Cruz (UCSC) to explore whether lab-grown human brain tissues, known as brain organoids, can perform computations similar to artificial intelligence (AI) systems. The project, titled "EFRI BEGIN OI: Reinforcement Learning for Scalable Biocomputing," aims to establish a framework to uncover the learning and computational potential of human...
The National Science Foundation awarded a $1,064,877 project grant to the University of Pittsburgh under the Engineering program (CFDA 47.041) to support research titled "COLLABORATIVE RESEARCH: RECODE: DIRECTED DIFFERENTIATION OF HUMAN LIVER ORGANOIDS VIA COMPUTATIONAL ANALYSIS AND ENGINEERING OF GENE REGULATORY NETWORKS." The three-year award beginning January 1, 2022 will fund development of computational models to analyze gene regulatory networks and direct differentiation of human liver organoids for potential applications in disease modeling, drug discovery and regenerative medicine. The Engineering program aims to foster innovation and excellence in engineering research, and this project aligns with those goals by applying computational and engineering techniques to advance organoid technologies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 7/29/21 |