Project Grant 2515214
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will provide $1,958,603.00 to the University of California, Santa Cruz (UCSC) to explore whether lab-grown human brain tissues, known as brain organoids, can perform computations similar to artificial intelligence (AI) systems. The award, titled "EFRI BEGIN OI: REINFORCEMENT LEARNING FOR SCALABLE BIOCOMPUTING," will fund the development of tools that allow these brain organoids to...
- This $1,998,582 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support the development of biotechnology to grow cellular brain organoids capable of replicating network and activity observed in the human brain. The research team at The University of Texas at San Antonio (UTSA) will integrate these brain organoids into an engineered system and program them to solve increasingly complex associative problems, evaluating how this bioengineering...
- This $200,000 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to establish a closed-loop hybrid intelligence (HI) framework that connects biological and physical computing systems. The research project will co-design high-resolution optoelectronic neuromodulation and neuromorphic hardware to enable closed-loop interfacing with cultured neurons and organoids. The HI system will showcase the power of optogenetic-neuromorphic co-design for...
- This $2,000,000 Project Grant awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support a research project at Boise State University to explore how brain-like structures grown in the lab, known as brain organoids, can be trained to control muscle contractions. The goal is to harness the power of biological neural networks to create low-power, adaptable computing systems that could have applications in healthcare, robotics, and national defense. The...
- The National Science Foundation (NSF) Engineering Directorate awarded a $564,510 Project Grant to the University of Massachusetts (UMass) to develop an engineered neural organoid system with improved brain regionalization and integrated mesh electrodes for enhanced monitoring and stimulation capabilities. The key objectives of this 3-year grant project are to: 1) Assemble regionalized neural organoids that enable thalamus-subpallium-cortex projections by stacking sliced organoids, 2) Innervate...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $100,000 Project Grant to Boise State University to conduct planning activities related to "Organoid-Directed Muscle Control." The grant aims to broaden participation in this research area by engaging national leaders, forming vertically integrated research teams, and developing an understanding of the ethical, legal, and social implications of biocomputing through engineered organoid intelligence. Key...
- This $1,999,112 project grant from the National Science Foundation's Engineering Directorate (NSF ENG) will fund research at The Johns Hopkins University to develop new artificial intelligence techniques inspired by neuroscience models of visual attention. Specifically, the grant aims to translate models of visual attention in mammalian brains into new deep learning algorithms that can greatly reduce the number of variables updated during machine learning. If successful, these brain-inspired...
- This $1.5 million Project Grant from the National Science Foundation (NSF), under the Engineering federal grant program (CFDA 47.041), will fund research at the University of California Irvine from October 2022 through September 2026. The university will develop hydrogel-based bioengineering technologies to reproducibly generate distinct spatial organization and cellular diversity within cortical organoids, mimicking the development of different brain regions. Researchers will leverage expertise...
- This $2,000,000 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support a project at Lehigh University to explore the use of layered biological neural networks for processing dynamic visual information. The project aims to develop functional and structural networks in multilayer neuronal organoids that can mimic the visual pathway in the brain, with the goal of enabling improved object identification in video. Ethical, legal, and social...
- The National Science Foundation's Engineering program (CFDA 47.041) awarded a $399,728 Project Grant to the University of North Carolina at Chapel Hill (UNC-CH) to develop a new technology called "HOTPOCKET" - a soft, flexible electronic system that can gently wrap around brain organoids to study their electrical activity over long periods. This project aims to create a reliable method for connecting with and studying brain organoids, which are lab-grown models that mimic parts of...
The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded The Johns Hopkins University a $1,999,508.00 Project Grant to advance the field of Organoid Intelligence (OI). The project seeks to incorporate reward-based learning mechanisms into lab-grown brain organoids to enable more complex and adaptive behaviors, with the goal of creating computing devices that use substantially less energy than today's AI systems. The research team will connect the brain organoids to electronic shells and use chemical signals to teach them to play simple video games and guide small robots. Throughout the project, bioethicists will monitor the research to ensure responsible and ethical conduct. The work will also train students, create open-source hardware and software, and launch community courses to engage citizen scientists in learning about biological computing. Successful completion of this 4-year project could pave the way for energy-efficient computing and open new paths for studying disorders like Alzheimer's disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/26/25 | ||
| Not listed | $2.0m | 8/15/25 |